CSTM1_ARATH
ID CSTM1_ARATH Reviewed; 72 AA.
AC O23035;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 1 {ECO:0000303|PubMed:29272523};
DE Short=AthCYSTM1 {ECO:0000303|PubMed:29272523};
GN Name=CYSTM1 {ECO:0000303|PubMed:29272523};
GN OrderedLocusNames=At1g05340 {ECO:0000312|Araport:AT1G05340};
GN ORFNames=YUP8H12.4 {ECO:0000312|EMBL:AAB71443.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION.
RX PubMed=12805622; DOI=10.1104/pp.103.023085;
RA Hoekenga O.A., Vision T.J., Shaff J.E., Monforte A.J., Lee G.P.,
RA Howell S.H., Kochian L.V.;
RT "Identification and characterization of aluminium tolerance loci in
RT Arabidopsis (Landsberg erecta x Columbia) by quantitative trait locus
RT mapping. A physiologically simple but genetically complex trait.";
RL Plant Physiol. 132:936-948(2003).
RN [7]
RP FUNCTION, INTERACTION WITH CYSTM7 AND WIH1/CYSTM13, TISSUE SPECIFICITY,
RP INDUCTION BY OXIDATION AND DROUGHT, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=29272523; DOI=10.1093/pcp/pcx202;
RA Xu Y., Yu Z., Zhang D., Huang J., Wu C., Yang G., Yan K., Zhang S.,
RA Zheng C.;
RT "CYSTM, a novel non-secreted cysteine-rich peptide family, involved in
RT environmental stresses in Arabidopsis thaliana.";
RL Plant Cell Physiol. 59:423-438(2018).
CC -!- FUNCTION: May be involved in aluminium (Al) tolerance
CC (PubMed:12805622). Involved in resistance to abiotic stress
CC (PubMed:29272523). {ECO:0000269|PubMed:12805622,
CC ECO:0000303|PubMed:29272523}.
CC -!- SUBUNIT: Heterodimers (PubMed:29272523). Binds weakly to CYSTM7 and
CC WIH1/CYSTM13 (PubMed:29272523). {ECO:0000269|PubMed:29272523}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29272523};
CC Single-pass membrane protein {ECO:0000255}. Nucleus
CC {ECO:0000269|PubMed:29272523}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in roots, flowers and siliques
CC and, to a lower extent, in stems and leaves.
CC {ECO:0000269|PubMed:29272523}.
CC -!- INDUCTION: Induced by drought and oxidation stress.
CC {ECO:0000269|PubMed:29272523}.
CC -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC000098; AAB71443.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27827.1; -; Genomic_DNA.
DR EMBL; AF360144; AAK25854.1; -; mRNA.
DR EMBL; AY056369; AAL07255.1; -; mRNA.
DR EMBL; AK226423; BAE98567.1; -; mRNA.
DR EMBL; AY085980; AAM63190.1; -; mRNA.
DR PIR; C86188; C86188.
DR RefSeq; NP_563734.1; NM_100413.4.
DR AlphaFoldDB; O23035; -.
DR STRING; 3702.AT1G05340.1; -.
DR PaxDb; O23035; -.
DR EnsemblPlants; AT1G05340.1; AT1G05340.1; AT1G05340.
DR GeneID; 837033; -.
DR Gramene; AT1G05340.1; AT1G05340.1; AT1G05340.
DR KEGG; ath:AT1G05340; -.
DR Araport; AT1G05340; -.
DR TAIR; locus:2207195; AT1G05340.
DR eggNOG; ENOG502S924; Eukaryota.
DR HOGENOM; CLU_128451_2_2_1; -.
DR InParanoid; O23035; -.
DR OMA; DHNQSAG; -.
DR OrthoDB; 1607719at2759; -.
DR PhylomeDB; O23035; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O23035; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR InterPro; IPR028144; CYSTM_dom.
DR InterPro; IPR044850; WIH2-like.
DR PANTHER; PTHR31568; PTHR31568; 1.
DR Pfam; PF12734; CYSTM; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..72
FT /note="Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 1"
FT /id="PRO_0000454798"
FT TRANSMEM 49..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 72 AA; 7480 MW; 644B8097A9C35523 CRC64;
MSQYDHNQSA GANPPPPMST CTSPPPPIGY PTNQPSHGSV AQGKVETKSK GDGFFKGCLA
AMCCCCALDI CF
