CSTM3_ARATH
ID CSTM3_ARATH Reviewed; 71 AA.
AC A0A178WF56; A0A1P8ANL9;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 1.
DT 03-AUG-2022, entry version 28.
DE RecName: Full=Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 3 {ECO:0000303|PubMed:29272523};
DE Short=AthCYSTM3 {ECO:0000303|PubMed:29272523};
GN Name=CYSTM3 {ECO:0000303|PubMed:29272523};
GN OrderedLocusNames=At1g56060 {ECO:0000312|Araport:AT1G56060};
GN ORFNames=T6H22.17 {ECO:0000312|EMBL:ANM58233.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, INTERACTION WITH CYSTM7 AND WIH1/CYSTM13, TISSUE SPECIFICITY,
RP INDUCTION BY SALT; COLD AND DROUGHT, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=29272523; DOI=10.1093/pcp/pcx202;
RA Xu Y., Yu Z., Zhang D., Huang J., Wu C., Yang G., Yan K., Zhang S.,
RA Zheng C.;
RT "CYSTM, a novel non-secreted cysteine-rich peptide family, involved in
RT environmental stresses in Arabidopsis thaliana.";
RL Plant Cell Physiol. 59:423-438(2018).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, INDUCTION BY SALT
RP STRESS, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=30701352; DOI=10.1007/s11103-019-00825-x;
RA Xu Y., Yu Z., Zhang S., Wu C., Yang G., Yan K., Zheng C., Huang J.;
RT "CYSTM3 negatively regulates salt stress tolerance in Arabidopsis.";
RL Plant Mol. Biol. 99:395-406(2019).
CC -!- FUNCTION: Regulates negatively salt stress responses and Na(+)
CC homeostasis (PubMed:29272523, PubMed:30701352). Prevents Na(+) efflux,
CC disturbs reactive oxygen species (ROS) homeostasis, and represses the
CC expression of nuclear salt stress-responsive genes (PubMed:30701352).
CC Involved in resistance to abiotic stress (PubMed:29272523).
CC {ECO:0000269|PubMed:29272523, ECO:0000269|PubMed:30701352,
CC ECO:0000303|PubMed:29272523}.
CC -!- SUBUNIT: Heterodimers (PubMed:29272523). Interacts with CYSTM7 and
CC WIH1/CYSTM13 (PubMed:29272523). {ECO:0000269|PubMed:29272523}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29272523};
CC Single-pass membrane protein {ECO:0000255}. Cytoplasm
CC {ECO:0000269|PubMed:29272523}. Mitochondrion
CC {ECO:0000269|PubMed:30701352}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in leaves and flowers and, to a
CC lower extent, in stems, siliques, shoots and roots.
CC {ECO:0000269|PubMed:29272523, ECO:0000269|PubMed:30701352}.
CC -!- INDUCTION: Induced by salt, cold and drought.
CC {ECO:0000269|PubMed:29272523, ECO:0000269|PubMed:30701352}.
CC -!- DISRUPTION PHENOTYPE: Increased tolerance to high salinity with reduced
CC reactive oxygen species (ROS) levels and associated with an over-
CC activation of nuclear salt stress-responsive genes.
CC {ECO:0000269|PubMed:30701352}.
CC -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
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DR EMBL; AC009894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; ANM58233.1; -; Genomic_DNA.
DR RefSeq; NP_176002.1; NM_104484.3.
DR STRING; 3702.AT1G56060.1; -.
DR EnsemblPlants; AT1G56060.2; AT1G56060.2; AT1G56060.
DR GeneID; 842057; -.
DR Gramene; AT1G56060.2; AT1G56060.2; AT1G56060.
DR Araport; AT1G56060; -.
DR eggNOG; ENOG502R1RQ; Eukaryota.
DR OMA; AMEGPYV; -.
DR OrthoDB; 1574600at2759; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A0A178WF56; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:1901001; P:negative regulation of response to salt stress; IMP:UniProtKB.
DR GO; GO:1903426; P:regulation of reactive oxygen species biosynthetic process; IMP:UniProtKB.
DR GO; GO:0009651; P:response to salt stress; IEP:UniProtKB.
DR GO; GO:0055078; P:sodium ion homeostasis; IMP:UniProtKB.
DR InterPro; IPR028144; CYSTM_dom.
DR InterPro; IPR044850; WIH2-like.
DR PANTHER; PTHR31568; PTHR31568; 1.
DR Pfam; PF12734; CYSTM; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..71
FT /note="Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 3"
FT /id="PRO_0000454800"
FT TRANSMEM 48..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 30..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 71 AA; 7812 MW; CA05BD59F8B5832E CRC64;
MAQYHQQHEM KQTMAETQYV TAPPPMGYPV MMKDSPQTVQ PPHEGQSKGS GGFLRGCLAA
MCCCCVLDCV F
