CSTM5_ARATH
ID CSTM5_ARATH Reviewed; 75 AA.
AC Q1PEX8; A0MER3; Q9SKY0;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 5 {ECO:0000303|PubMed:29272523};
DE Short=AthCYSTM5 {ECO:0000303|PubMed:29272523};
GN Name=CYSTM5 {ECO:0000303|PubMed:29272523};
GN OrderedLocusNames=At2g32200 {ECO:0000312|Araport:AT2G32200};
GN ORFNames=F22D22.5 {ECO:0000312|EMBL:AAD15385.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP FUNCTION, INTERACTION WITH CYSTM7 AND WIH1/CYSTM13, TISSUE SPECIFICITY,
RP INDUCTION BY HEAT; COLD; DROUGHT; OXIDATION AND SALT, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=29272523; DOI=10.1093/pcp/pcx202;
RA Xu Y., Yu Z., Zhang D., Huang J., Wu C., Yang G., Yan K., Zhang S.,
RA Zheng C.;
RT "CYSTM, a novel non-secreted cysteine-rich peptide family, involved in
RT environmental stresses in Arabidopsis thaliana.";
RL Plant Cell Physiol. 59:423-438(2018).
CC -!- FUNCTION: Involved in resistance to abiotic stress.
CC {ECO:0000303|PubMed:29272523}.
CC -!- SUBUNIT: Heterodimers (PubMed:29272523). Interacts with CYSTM7 and
CC WIH1/CYSTM13 (PubMed:29272523). {ECO:0000269|PubMed:29272523}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29272523};
CC Single-pass membrane protein {ECO:0000255}. Nucleus
CC {ECO:0000269|PubMed:29272523}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in roots, stems, rosette leaves
CC and siliques and, to a lower extent, in flowers and cauline leaves.
CC {ECO:0000269|PubMed:29272523}.
CC -!- INDUCTION: Induced by heat in roots, but suppressed in shoots
CC (PubMed:29272523). Accumulates in response to cold, drought, oxidation
CC stress and salt (PubMed:29272523). {ECO:0000269|PubMed:29272523}.
CC -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD15385.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ABK28521.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC006223; AAD15385.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08649.1; -; Genomic_DNA.
DR EMBL; DQ446589; ABE65881.1; -; mRNA.
DR EMBL; DQ653035; ABK28521.1; ALT_SEQ; mRNA.
DR PIR; B84730; B84730.
DR RefSeq; NP_180779.2; NM_128779.4.
DR PaxDb; Q1PEX8; -.
DR EnsemblPlants; AT2G32200.1; AT2G32200.1; AT2G32200.
DR EnsemblPlants; AT2G32200.2; AT2G32200.2; AT2G32200.
DR GeneID; 817779; -.
DR Gramene; AT2G32200.1; AT2G32200.1; AT2G32200.
DR Gramene; AT2G32200.2; AT2G32200.2; AT2G32200.
DR Araport; AT2G32200; -.
DR TAIR; locus:2045507; AT2G32200.
DR HOGENOM; CLU_128451_2_2_1; -.
DR InParanoid; Q1PEX8; -.
DR OMA; HTTHATV; -.
DR PhylomeDB; Q1PEX8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q1PEX8; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR InterPro; IPR028144; CYSTM_dom.
DR InterPro; IPR044850; WIH2-like.
DR PANTHER; PTHR31568; PTHR31568; 1.
DR Pfam; PF12734; CYSTM; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..75
FT /note="Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 5"
FT /id="PRO_0000454802"
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 75 AA; 7800 MW; 26E775190686E507 CRC64;
MSQYSQNQYA GAYPTPPVST GPYVAPPPLG YPTNDTTHAT VAPVETKSKG EAADGFLKGC
LATMLACCVL DACIF
