CSTM8_ARATH
ID CSTM8_ARATH Reviewed; 71 AA.
AC Q8W472;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 8 {ECO:0000303|PubMed:29272523};
DE Short=AthCYSTM8 {ECO:0000303|PubMed:29272523};
GN Name=CYSTM8 {ECO:0000303|PubMed:29272523};
GN OrderedLocusNames=At3g22235 {ECO:0000312|Araport:AT3G22235};
GN ORFNames=MKA23 {ECO:0000312|EMBL:AP001306};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION BY SALT; HEAT; COLD AND DROUGHT,
RP AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=29272523; DOI=10.1093/pcp/pcx202;
RA Xu Y., Yu Z., Zhang D., Huang J., Wu C., Yang G., Yan K., Zhang S.,
RA Zheng C.;
RT "CYSTM, a novel non-secreted cysteine-rich peptide family, involved in
RT environmental stresses in Arabidopsis thaliana.";
RL Plant Cell Physiol. 59:423-438(2018).
CC -!- FUNCTION: Involved in resistance to abiotic stress.
CC {ECO:0000303|PubMed:29272523}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:29272523}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in stems, siliques, roots and
CC flowers and, to a lower extent, in leaves.
CC {ECO:0000269|PubMed:29272523}.
CC -!- INDUCTION: Induced by heat in shoots, but suppressed in roots
CC (PubMed:29272523). Repressed in roots in response to cold, drought and
CC salt (PubMed:29272523). {ECO:0000269|PubMed:29272523}.
CC -!- SIMILARITY: Belongs to the CYSTM1 family. {ECO:0000305}.
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DR EMBL; AP001306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002686; AEE76609.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76610.1; -; Genomic_DNA.
DR EMBL; AK119141; BAC43711.1; -; mRNA.
DR EMBL; AY062802; AAL32880.1; -; mRNA.
DR EMBL; AY081616; AAM10178.1; -; mRNA.
DR RefSeq; NP_001154638.1; NM_001161166.2.
DR RefSeq; NP_850623.4; NM_180292.5.
DR STRING; 3702.AT3G22235.1; -.
DR PaxDb; Q8W472; -.
DR PRIDE; Q8W472; -.
DR ProteomicsDB; 252043; -.
DR EnsemblPlants; AT3G22235.1; AT3G22235.1; AT3G22235.
DR EnsemblPlants; AT3G22235.2; AT3G22235.2; AT3G22235.
DR GeneID; 821791; -.
DR Gramene; AT3G22235.1; AT3G22235.1; AT3G22235.
DR Gramene; AT3G22235.2; AT3G22235.2; AT3G22235.
DR KEGG; ath:AT3G22235; -.
DR Araport; AT3G22235; -.
DR TAIR; locus:1005716535; AT3G22235.
DR HOGENOM; CLU_128451_4_0_1; -.
DR OMA; GMMNPPP; -.
DR OrthoDB; 1607719at2759; -.
DR PhylomeDB; Q8W472; -.
DR Proteomes; UP000006548; Chromosome 3.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR InterPro; IPR028144; CYSTM_dom.
DR InterPro; IPR044850; WIH2-like.
DR PANTHER; PTHR31568; PTHR31568; 1.
DR Pfam; PF12734; CYSTM; 1.
PE 2: Evidence at transcript level;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..71
FT /note="Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 8"
FT /id="PRO_0000454805"
FT TRANSMEM 48..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 71 AA; 7317 MW; B06D3EBB35F5D46A CRC64;
MNQSAQNYFS VQKPSETSSG PYTSPPPIGY PTRDAVVGDP PAAAVETNSK GVNPEGCCAA
ICCCCVLDAC F
