ID   CSTOS_BOVIN             Reviewed;         257 AA.
AC   Q58CQ0; Q58CS2;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Protein CUSTOS {ECO:0000250|UniProtKB:A9C3N6};
GN   Name=CUSTOS {ECO:0000250|UniProtKB:A9C3N6};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Plays a role in the regulation of Wnt signaling pathway
CC       during early development. {ECO:0000250|UniProtKB:A9C3N6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:A9C3N6}.
CC   -!- SIMILARITY: Belongs to the CUSTOS family. {ECO:0000305}.
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DR   EMBL; BT021875; AAX46722.1; -; mRNA.
DR   EMBL; BT021897; AAX46744.1; -; mRNA.
DR   EMBL; BT029879; ABM21557.1; -; mRNA.
DR   RefSeq; NP_001026923.1; NM_001031753.1.
DR   RefSeq; XP_005217824.1; XM_005217767.3.
DR   AlphaFoldDB; Q58CQ0; -.
DR   SMR; Q58CQ0; -.
DR   STRING; 9913.ENSBTAP00000029052; -.
DR   PaxDb; Q58CQ0; -.
DR   PRIDE; Q58CQ0; -.
DR   GeneID; 507351; -.
DR   KEGG; bta:507351; -.
DR   CTD; 121079804; -.
DR   eggNOG; ENOG502S3AI; Eukaryota.
DR   OrthoDB; 1545516at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0060061; P:Spemann organizer formation; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR026694; CUSTOS.
DR   PANTHER; PTHR14482; PTHR14482; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Phosphoprotein; Reference proteome;
KW   Wnt signaling pathway.
FT   CHAIN           1..257
FT                   /note="Protein CUSTOS"
FT                   /id="PRO_0000276849"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           228..236
FT                   /note="Nucleolar localization signal (NLS)"
FT                   /evidence="ECO:0000250|UniProtKB:A9C3N6"
FT   COMPBIAS        143..157
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         55
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96C57"
FT   MOD_RES         73
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96C57"
FT   CONFLICT        57
FT                   /note="M -> R (in Ref. 1; AAX46722/ABM21557)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        146
FT                   /note="Missing (in Ref. 1; AAX46722/ABM21557)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        201
FT                   /note="T -> A (in Ref. 1; AAX46722/ABM21557)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        207
FT                   /note="E -> A (in Ref. 1; AAX46722/ABM21557)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        244
FT                   /note="L -> P (in Ref. 1; AAX46722/ABM21557)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   257 AA;  27813 MW;  9D0723AA73C4F8D9 CRC64;
     MSDLESSSSS SSDEEELERC REAALPAWGL EQRPRGPEKP GVDATNAKLP ANQPSLMHKV
     DEHEQDGNEL QTTPEFRAHV AKKLGALLDS SITISEIVKE PRKSEVQQGA LEDDGFRLFF
     TSIPGGPEKE AAPQPCRKRL PSSSSSDDGD EELRRCREAA VSASDILQES AIHGHVSVEK
     KKKRKLKKKA KKEDSADVAA TATSKAEVGR QEKESAQLNG DQAPPGTKKK KRKKKTKKAS
     EASLSPPTKS AAAVPSN