CSTOS_MOUSE
ID CSTOS_MOUSE Reviewed; 256 AA.
AC Q3UY34; Q3TX98; Q8K0K9; Q9CVB7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Protein CUSTOS {ECO:0000250|UniProtKB:A9C3N6};
GN Name=Custos {ECO:0000250|UniProtKB:A9C3N6};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in the regulation of Wnt signaling pathway
CC during early development. {ECO:0000250|UniProtKB:A9C3N6}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:A9C3N6}.
CC -!- SIMILARITY: Belongs to the CUSTOS family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK008740; BAB25869.1; -; mRNA.
DR EMBL; AK135000; BAE22379.1; -; mRNA.
DR EMBL; AK159360; BAE35018.1; -; mRNA.
DR EMBL; BC031162; AAH31162.1; -; mRNA.
DR CCDS; CCDS19576.1; -.
DR RefSeq; NP_082487.1; NM_028211.1.
DR AlphaFoldDB; Q3UY34; -.
DR STRING; 10090.ENSMUSP00000031538; -.
DR iPTMnet; Q3UY34; -.
DR PhosphoSitePlus; Q3UY34; -.
DR EPD; Q3UY34; -.
DR MaxQB; Q3UY34; -.
DR PaxDb; Q3UY34; -.
DR PeptideAtlas; Q3UY34; -.
DR PRIDE; Q3UY34; -.
DR DNASU; 72357; -.
DR GeneID; 72357; -.
DR KEGG; mmu:72357; -.
DR UCSC; uc008zcy.1; mouse.
DR MGI; MGI:1919607; 2210016L21Rik.
DR eggNOG; ENOG502S3AI; Eukaryota.
DR InParanoid; Q3UY34; -.
DR OrthoDB; 1545516at2759; -.
DR PhylomeDB; Q3UY34; -.
DR TreeFam; TF336221; -.
DR BioGRID-ORCS; 72357; 2 hits in 71 CRISPR screens.
DR ChiTaRS; 2210016L21Rik; mouse.
DR PRO; PR:Q3UY34; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3UY34; protein.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0060061; P:Spemann organizer formation; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR026694; CUSTOS.
DR PANTHER; PTHR14482; PTHR14482; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Nucleus; Phosphoprotein; Reference proteome;
KW Wnt signaling pathway.
FT CHAIN 1..256
FT /note="Protein CUSTOS"
FT /id="PRO_0000276851"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 228..235
FT /note="Nucleolar localization signal (NLS)"
FT /evidence="ECO:0000250|UniProtKB:A9C3N6"
FT COMPBIAS 7..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 62
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96C57"
FT MOD_RES 80
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96C57"
FT MOD_RES 139
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96C57"
SQ SEQUENCE 256 AA; 27631 MW; 1A1A49C83836E1BC CRC64;
MVAPSGAMSD SENSSSSSSD AEELARCREA ATPAWGLEQR PGAAERPEAG AADKQAPTPQ
PSRRHEVNQH EEDGNDLRTT PEFRAHVAKK LGALLDSSIA IAEVWKKSQK AKMQQVAKEE
DGFRLFFTSI PGGHKKEASP RPCRKRQPPS SSEDSDEELQ RCREAAVSAS DILQESAIHC
PAKAEEKKKL KKKAKKKVDN ADLAAAPGLE QVKEAGVVNG DPVSLGIQKK RKKKAKKSRE
APLCPPAECA AAKPEN
