ID   CSTOS_RAT               Reviewed;         277 AA.
AC   Q5I034;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Protein CUSTOS {ECO:0000250|UniProtKB:A9C3N6};
GN   Name=Custos {ECO:0000250|UniProtKB:A9C3N6};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Plays a role in the regulation of Wnt signaling pathway
CC       during early development. {ECO:0000250|UniProtKB:A9C3N6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:A9C3N6}.
CC   -!- SIMILARITY: Belongs to the CUSTOS family. {ECO:0000305}.
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DR   EMBL; BC088751; AAH88751.1; -; mRNA.
DR   RefSeq; NP_001009630.1; NM_001009630.1.
DR   AlphaFoldDB; Q5I034; -.
DR   STRING; 10116.ENSRNOP00000050415; -.
DR   iPTMnet; Q5I034; -.
DR   PhosphoSitePlus; Q5I034; -.
DR   jPOST; Q5I034; -.
DR   PaxDb; Q5I034; -.
DR   PRIDE; Q5I034; -.
DR   Ensembl; ENSRNOT00000050782; ENSRNOP00000050415; ENSRNOG00000001185.
DR   GeneID; 288704; -.
DR   KEGG; rno:288704; -.
DR   CTD; 288704; -.
DR   RGD; 1311899; RGD1311899.
DR   eggNOG; ENOG502S3AI; Eukaryota.
DR   GeneTree; ENSGT00390000010771; -.
DR   HOGENOM; CLU_092827_0_0_1; -.
DR   InParanoid; Q5I034; -.
DR   OMA; RPCRKRQ; -.
DR   OrthoDB; 1545516at2759; -.
DR   PhylomeDB; Q5I034; -.
DR   TreeFam; TF336221; -.
DR   PRO; PR:Q5I034; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000001185; Expressed in cerebellum and 20 other tissues.
DR   Genevisible; Q5I034; RN.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0060061; P:Spemann organizer formation; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR026694; CUSTOS.
DR   PANTHER; PTHR14482; PTHR14482; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Developmental protein; Nucleus; Phosphoprotein;
KW   Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..277
FT                   /note="Protein CUSTOS"
FT                   /id="PRO_0000276852"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          106..141
FT                   /evidence="ECO:0000255"
FT   MOTIF           249..256
FT                   /note="Nucleolar localization signal (NLS)"
FT   COMPBIAS        64..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..143
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         62
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96C57"
FT   MOD_RES         80
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96C57"
FT   MOD_RES         158
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96C57"
FT   MOD_RES         238
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   277 AA;  30056 MW;  F47823CFE80CAC20 CRC64;
     MVAPSGAMSD SESSSSDSSD AEELARCREA ATPAWGLEQR PREAERPAAG TADTQAPAPQ
     PSRRREVNQH DEDGNELQTT PEFRAYVAKK LGALLDSSIA IAEVWKKTQQ ARLQQEAKEQ
     QEAKEQQAAK EEQAAKKEED GFRLFFTSVP GGHEKEASPR PCRKRQPPSS SEDSDEELQR
     CREAAVSASD ILQESAIHCP AKVEKEAEKK KLKKKAKKKA DADLAAATGL EQVKEAGSVN
     GDPVLSGTKK KKKKKAKKAR EASLCPPAEC AAAEPKN