ID   CSTP1_BOVIN             Reviewed;         326 AA.
AC   Q32KQ7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Centriolar satellite-associated tubulin polyglutamylase complex regulator 1;
GN   Name=CSTPP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the tubulin polyglutamylase complex (TPGC) that
CC       controls cytoskeletal organization, nuclear shape, and cilium
CC       disassembly by balancing microtubule and actin assembly. Regulates the
CC       assembly and stability of the TPGC and thereby modulates
CC       polyglutamylation of the microtubule, which antagonizes MAP4 binding.
CC       {ECO:0000250|UniProtKB:Q9H6J7}.
CC   -!- SUBUNIT: Interacts with PCM1. Interacts with TTLL1, TPGS1, TPGS2 and
CC       LRRC49; the interactions link CSTPP1 to the complex TPGC. Binds to
CC       alpha-tubulin. {ECO:0000250|UniProtKB:Q9H6J7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriolar satellite
CC       {ECO:0000250|UniProtKB:Q9H6J7}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q9H6J7}. Note=Associated with microtubules.
CC       {ECO:0000250|UniProtKB:Q9H6J7}.
CC   -!- SIMILARITY: Belongs to the CSTPP1 family. {ECO:0000305}.
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DR   EMBL; BC109973; AAI09974.1; -; mRNA.
DR   RefSeq; NP_001033126.1; NM_001038037.2.
DR   AlphaFoldDB; Q32KQ7; -.
DR   STRING; 9913.ENSBTAP00000039371; -.
DR   PaxDb; Q32KQ7; -.
DR   PRIDE; Q32KQ7; -.
DR   GeneID; 505437; -.
DR   KEGG; bta:505437; -.
DR   CTD; 79096; -.
DR   eggNOG; ENOG502QRVN; Eukaryota.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038968; C11orf49.
DR   PANTHER; PTHR34252; PTHR34252; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Centriolar satellite-associated tubulin
FT                   polyglutamylase complex regulator 1"
FT                   /id="PRO_0000281424"
FT   REGION          1..225
FT                   /note="Required for interaction with TPGS1, LRRC49, and
FT                   TTLL1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6J7"
FT   REGION          1..111
FT                   /note="Required for interaction with PCM1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6J7"
SQ   SEQUENCE   326 AA;  37423 MW;  EC96D7C59583786C CRC64;
     MLSPERLALP DYEYLAQRHV LTYVEDAVCQ LLENKEDISQ YGIARFFTEY FNSVCQGTHI
     LFREFSFIQA TPHNRASFLR AFWRCFRTVG KNGDLLTMRE YHCLLQLLCP DFPLELTQKA
     ARIVLMDDAM DCLMSFSDFL FAFQIQFYYS EFLESVAAIY QDLLSGKNPN TVIVPTSSSG
     QHRHRPSTGE AGTPEGVEAS LFYQCLENLC DRHKYSCPPP ALVKEVLSNV QRLTFYGFLV
     ALSKHHGINQ ALGALPDKGD LMHDPAMDEE LERLVLRWRP HRSSRQHRAK EPGAFGYQRR
     DKLEALQTVP PASAPTPCLY QWEPIE