ID   CSTP1_PONAB             Reviewed;         331 AA.
AC   Q5RC14;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Centriolar satellite-associated tubulin polyglutamylase complex regulator 1;
GN   Name=CSTPP1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the tubulin polyglutamylase complex (TPGC) that
CC       controls cytoskeletal organization, nuclear shape, and cilium
CC       disassembly by balancing microtubule and actin assembly. Regulates the
CC       assembly and stability of the TPGC and thereby modulates
CC       polyglutamylation of the microtubule, which antagonizes MAP4 binding.
CC       {ECO:0000250|UniProtKB:Q9H6J7}.
CC   -!- SUBUNIT: Interacts with PCM1. Interacts with TTLL1, TPGS1, TPGS2 and
CC       LRRC49; the interactions link CSTPP1 to the complex TPGC. Binds to
CC       alpha-tubulin. {ECO:0000250|UniProtKB:Q9H6J7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriolar satellite
CC       {ECO:0000250|UniProtKB:Q9H6J7}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q9H6J7}. Note=Associated with microtubules.
CC       {ECO:0000250|UniProtKB:Q9H6J7}.
CC   -!- SIMILARITY: Belongs to the CSTPP1 family. {ECO:0000305}.
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DR   EMBL; CR858468; CAH90696.1; -; mRNA.
DR   RefSeq; NP_001127323.1; NM_001133851.2.
DR   AlphaFoldDB; Q5RC14; -.
DR   STRING; 9601.ENSPPYP00000003803; -.
DR   GeneID; 100174384; -.
DR   KEGG; pon:100174384; -.
DR   CTD; 79096; -.
DR   eggNOG; ENOG502QRVN; Eukaryota.
DR   HOGENOM; CLU_064579_0_0_1; -.
DR   InParanoid; Q5RC14; -.
DR   OMA; NIHHRRK; -.
DR   OrthoDB; 1103030at2759; -.
DR   TreeFam; TF329168; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038968; C11orf49.
DR   PANTHER; PTHR34252; PTHR34252; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Reference proteome.
FT   CHAIN           1..331
FT                   /note="Centriolar satellite-associated tubulin
FT                   polyglutamylase complex regulator 1"
FT                   /id="PRO_0000281428"
FT   REGION          1..225
FT                   /note="Required for interaction with TPGS1, LRRC49, and
FT                   TTLL1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6J7"
FT   REGION          1..111
FT                   /note="Required for interaction with PCM1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6J7"
FT   REGION          112..331
FT                   /note="Required for interaction with TPGS2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6J7"
FT   REGION          288..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         319
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHR8"
SQ   SEQUENCE   331 AA;  37436 MW;  C39CBD3DD0409079 CRC64;
     MLSPERLALP DYEYLAQRHV LTYMEDAVCQ LLENREDISQ YGIARFFTEY FNSVCQGTHI
     LFREFSFVQA TPHNRVSFLR AFWRCFRTVG KNGDLLTMKE YHCLLQLLCP DFPLELTQKA
     ARIVLMDDAM DCLMSFSDFL FAFQIQFYYS EFLDSVAAIY ENLLSGKNPN TVIVPTSSSG
     QHRQRPALGE AGMLEGVEAS LFYQCLENLC DRHKYSCPPP ALVKEALSNV QRLTFYGFLM
     ALSKHHGINQ ALGALPDKGD LMHDPAMDEE LERLLAQVPG LVNSVTASPE ASCLPSRTPP
     RVGSPWRPLH HSRKVDGESD GSTEETDESE T