CSTR1_ARATH
ID CSTR1_ARATH Reviewed; 340 AA.
AC Q8LGE9; Q9FJ38;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=CMP-sialic acid transporter 1;
DE Short=CMP-SA-Tr 1;
DE Short=CMP-Sia-Tr 1;
GN OrderedLocusNames=At5g41760; ORFNames=K16L22.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=15456736; DOI=10.1093/glycob/cwh159;
RA Bakker H., Routier F., Oelmann S., Jordi W., Lommen A., Gerardy-Schahn R.,
RA Bosch D.;
RT "Molecular cloning of two Arabidopsis UDP-galactose transporters by
RT complementation of a deficient Chinese hamster ovary cell line.";
RL Glycobiology 15:193-201(2005).
RN [6]
RP FUNCTION.
RX PubMed=18258224; DOI=10.1016/j.carres.2008.01.010;
RA Bakker H., Routier F., Ashikov A., Neumann D., Bosch D., Gerardy-Schahn R.;
RT "A CMP-sialic acid transporter cloned from Arabidopsis thaliana.";
RL Carbohydr. Res. 343:2148-2152(2008).
RN [7]
RP FUNCTION.
RX PubMed=19822337; DOI=10.1016/j.phytochem.2009.09.017;
RA Takashima S., Seino J., Nakano T., Fujiyama K., Tsujimoto M., Ishida N.,
RA Hashimoto Y.;
RT "Analysis of CMP-sialic acid transporter-like proteins in plants.";
RL Phytochemistry 70:1973-1981(2009).
RN [8]
RP GENE FAMILY.
RX PubMed=25053812; DOI=10.1073/pnas.1406073111;
RA Rautengarten C., Ebert B., Moreno I., Temple H., Herter T., Link B.,
RA Donas-Cofre D., Moreno A., Saez-Aguayo S., Blanco F., Mortimer J.C.,
RA Schultink A., Reiter W.D., Dupree P., Pauly M., Heazlewood J.L.,
RA Scheller H.V., Orellana A.;
RT "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter
RT family of Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:11563-11568(2014).
CC -!- FUNCTION: Essential protein. Sugar transporter involved in the
CC transport of CMP-sialic acid from the cytoplasm into the Golgi.
CC {ECO:0000269|PubMed:18258224, ECO:0000269|PubMed:19822337}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CMP-
CC Sialate:CMP antiporter (TC 2.A.7.12) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB10651.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB016871; BAB10651.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED94722.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94723.1; -; Genomic_DNA.
DR EMBL; BT004304; AAO42302.1; -; mRNA.
DR EMBL; BT005532; AAO63952.1; -; mRNA.
DR EMBL; AY084311; AAM60900.1; -; mRNA.
DR RefSeq; NP_001031992.1; NM_001036915.4.
DR RefSeq; NP_568596.1; NM_123541.5.
DR AlphaFoldDB; Q8LGE9; -.
DR SMR; Q8LGE9; -.
DR STRING; 3702.AT5G41760.2; -.
DR PaxDb; Q8LGE9; -.
DR PRIDE; Q8LGE9; -.
DR ProteomicsDB; 222717; -.
DR EnsemblPlants; AT5G41760.1; AT5G41760.1; AT5G41760.
DR EnsemblPlants; AT5G41760.2; AT5G41760.2; AT5G41760.
DR GeneID; 834180; -.
DR Gramene; AT5G41760.1; AT5G41760.1; AT5G41760.
DR Gramene; AT5G41760.2; AT5G41760.2; AT5G41760.
DR KEGG; ath:AT5G41760; -.
DR Araport; AT5G41760; -.
DR TAIR; locus:2152955; AT5G41760.
DR eggNOG; KOG2234; Eukaryota.
DR HOGENOM; CLU_024645_5_1_1; -.
DR InParanoid; Q8LGE9; -.
DR OMA; YSRIMPP; -.
DR OrthoDB; 754910at2759; -.
DR PhylomeDB; Q8LGE9; -.
DR PRO; PR:Q8LGE9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LGE9; baseline and differential.
DR Genevisible; Q8LGE9; AT.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015136; F:sialic acid transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0015739; P:sialic acid transport; IDA:UniProtKB.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..340
FT /note="CMP-sialic acid transporter 1"
FT /id="PRO_0000416024"
FT TOPO_DOM 1..5
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..36
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..102
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..200
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..282
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 340 AA; 38212 MW; 56F7B827C498A535 CRC64;
MAATPWYFVA VLLTILTSSQ GILTTLSQSD GGYKYDYATV PFLAEVFKLI ISGLFLWREM
RTSSSTTSRI TTDWKSVRLF VIPSLIYLIH NNVQFATLTY VDTSTYQIMG NLKIVTTGIL
FRLFLKRKLS KLQWMAIGLL AVGTTTSQVK GCGEASCDSL FTAPIQGYLL GILSAGLSAL
AGIYTEFLMK RNNDTLYWQN LQLYTFGSLF NVARLIADDF RHGFEKGPWW QRIFDGYSIT
TWLVVLNLGS TGLLVSWLMK YADNIVKVYS TSMAMLLTMV ASIYLFSFKP TLQLFLGIVI
CIMSLHMYFA PPHTLVDLPV TNEAHAKTLK QVVVEEKTDS
