CSTR1_ORYSI
ID CSTR1_ORYSI Reviewed; 322 AA.
AC B8B350;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=CMP-sialic acid transporter 1 {ECO:0000305};
DE Short=CMP-SA-Tr 1 {ECO:0000305};
DE Short=CMP-Sia-Tr 1 {ECO:0000305};
DE AltName: Full=CMP-sialic acid transporter-like protein 1 {ECO:0000305};
GN Name=CSTLP1 {ECO:0000305};
GN ORFNames=OsI_23192 {ECO:0000312|EMBL:EEC80726.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11 {ECO:0000312|Proteomes:UP000007015}, and
RC cv. Guang-Lu-Ai No.4;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
CC -!- FUNCTION: Sugar transporter involved in the transport of CMP-sialic
CC acid from the cytoplasm into the Golgi. May transport important
CC nucleotide sugars such as CMP-Kdo (2-keto-3-deoxy-D-manno-octulosonic
CC acid) in physiological conditions. {ECO:0000250|UniProtKB:Q654D9}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CMP-
CC Sialate:CMP antiporter (TC 2.A.7.12) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000131; EEC80726.1; -; Genomic_DNA.
DR AlphaFoldDB; B8B350; -.
DR SMR; B8B350; -.
DR STRING; 39946.B8B350; -.
DR EnsemblPlants; BGIOSGA021135-TA; BGIOSGA021135-PA; BGIOSGA021135.
DR Gramene; BGIOSGA021135-TA; BGIOSGA021135-PA; BGIOSGA021135.
DR HOGENOM; CLU_024645_5_1_1; -.
DR OMA; YSRIMPP; -.
DR Proteomes; UP000007015; Chromosome 6.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015136; F:sialic acid transmembrane transporter activity; IEA:EnsemblPlants.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..322
FT /note="CMP-sialic acid transporter 1"
FT /id="PRO_0000434338"
FT TOPO_DOM 1..2
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..33
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..100
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 127..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..157
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..233
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..286
FT /note="Lumenal"
FT /evidence="ECO:0000305"
SQ SEQUENCE 322 AA; 36567 MW; B62E9EAA7A2CDD0C CRC64;
MQWYLVAALL TVLTSSQGIL TTLSQSNGKY KYDYATIPFL AELFKLSFSS FFLWKECQSS
SPPRMTKEWR SIRLYLVPSV IYLIHNNVQF ATLTYVDPST YQIMGNLKIV TTGILFRLVL
KRKLSNLQWM AVVLLAVGTT TSQVKGCGDA PCDSLFSAPF QGYMLGILSA CLSALAGVYT
EYLMKKNNDS LYWQNVQLYT FGVIFNMGWL IYGDFKAGFE RGPWWQRLFN GYSITTWMVV
FNLGSTGLLV SWLMKYSDNI VKVYSTSMGM LLTMVLSVYL FNVRATLQLF LGIVICIISL
QMYFMPVNML VELPQALPVT SK
