CSTR1_ORYSJ
ID CSTR1_ORYSJ Reviewed; 322 AA.
AC Q654D9; A0A0P0WXP8;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=CMP-sialic acid transporter 1 {ECO:0000305};
DE Short=CMP-SA-Tr 1 {ECO:0000305};
DE Short=CMP-Sia-Tr 1 {ECO:0000305};
DE AltName: Full=CMP-sialic acid transporter-like protein 1 {ECO:0000303|PubMed:19822337};
DE Short=OsCSTLP1 {ECO:0000303|PubMed:19822337};
GN Name=CSTLP1 {ECO:0000303|PubMed:19822337};
GN OrderedLocusNames=Os06g0523400 {ECO:0000312|EMBL:BAF19667.1},
GN LOC_Os06g33210 {ECO:0000305};
GN ORFNames=OsJ_21524 {ECO:0000312|EMBL:EEE65803.1},
GN OSJNBa0009J19.27 {ECO:0000312|EMBL:BAD45826.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=19822337; DOI=10.1016/j.phytochem.2009.09.017;
RA Takashima S., Seino J., Nakano T., Fujiyama K., Tsujimoto M., Ishida N.,
RA Hashimoto Y.;
RT "Analysis of CMP-sialic acid transporter-like proteins in plants.";
RL Phytochemistry 70:1973-1981(2009).
CC -!- FUNCTION: Sugar transporter involved in the transport of CMP-sialic
CC acid from the cytoplasm into the Golgi. May transport important
CC nucleotide sugars such as CMP-Kdo (2-keto-3-deoxy-D-manno-octulosonic
CC acid) in physiological conditions. {ECO:0000269|PubMed:19822337}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves and stalks.
CC {ECO:0000269|PubMed:19822337}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CMP-
CC Sialate:CMP antiporter (TC 2.A.7.12) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP004730; BAD45826.1; -; Genomic_DNA.
DR EMBL; AP008212; BAF19667.1; -; Genomic_DNA.
DR EMBL; AP014962; BAS98020.1; -; Genomic_DNA.
DR EMBL; CM000143; EEE65803.1; -; Genomic_DNA.
DR EMBL; AK121890; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015641419.1; XM_015785933.1.
DR AlphaFoldDB; Q654D9; -.
DR SMR; Q654D9; -.
DR STRING; 4530.OS06T0523400-01; -.
DR PaxDb; Q654D9; -.
DR PRIDE; Q654D9; -.
DR EnsemblPlants; Os06t0523400-01; Os06t0523400-01; Os06g0523400.
DR GeneID; 4341175; -.
DR Gramene; Os06t0523400-01; Os06t0523400-01; Os06g0523400.
DR KEGG; osa:4341175; -.
DR eggNOG; KOG2234; Eukaryota.
DR HOGENOM; CLU_024645_5_1_1; -.
DR InParanoid; Q654D9; -.
DR OMA; YSRIMPP; -.
DR OrthoDB; 754910at2759; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000007752; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR Genevisible; Q654D9; OS.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015136; F:sialic acid transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0015739; P:sialic acid transport; IDA:UniProtKB.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..322
FT /note="CMP-sialic acid transporter 1"
FT /id="PRO_0000434337"
FT TOPO_DOM 1..2
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..33
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..100
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 127..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..157
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..233
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..286
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="M -> I (in Ref. 5; AK121890)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="L -> I (in Ref. 5; AK121890)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="L -> Q (in Ref. 5; AK121890)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 322 AA; 36581 MW; E0289EAA7A284BD7 CRC64;
MQWYLVAALL TVLTSSQGIL TTLSQSNGKY KYDYATIPFL AELFKLSFSS FFLWKECQSS
SPPRMTKEWR SIRLYLVPSV IYLIHNNVQF ATLTYVDPST YQIMGNLKIV TTGILFRLVL
KRKLSNLQWM AVVLLAVGTT TSQVKGCGDA PCDSLFSAPF QGYMLGILSA CLSALAGVYT
EYLMKKNNDS LYWQNVQLYT FGVIFNMGWL IYGDFKAGFE RGPWWQRLFN GYSITTWMVV
FNLGSTGLLV SWLMKYSDNI VKVYSTSMAM LLTMVLSVYL FNVRATLQLF LGIVICIISL
QMYFMPVNML VELPQALPVT SK
