CSTR2_ORYSI
ID CSTR2_ORYSI Reviewed; 356 AA.
AC B8B7Q4;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=CMP-sialic acid transporter 2 {ECO:0000305};
DE Short=CMP-SA-Tr 2 {ECO:0000305};
DE Short=CMP-Sia-Tr 2 {ECO:0000305};
DE AltName: Full=CMP-sialic acid transporter-like protein 2 {ECO:0000305};
GN Name=CSTLP2 {ECO:0000305};
GN ORFNames=OsI_26569 {ECO:0000312|EMBL:EEC82308.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11 {ECO:0000312|Proteomes:UP000007015}, and
RC cv. Guang-Lu-Ai No.4;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
CC -!- FUNCTION: Sugar transporter involved in the transport of CMP-sialic
CC acid from the cytoplasm into the Golgi. May transport important
CC nucleotide sugars such as CMP-Kdo (2-keto-3-deoxy-D-manno-octulosonic
CC acid) in physiological conditions. {ECO:0000250|UniProtKB:Q654D9}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CMP-
CC Sialate:CMP antiporter (TC 2.A.7.12) subfamily. {ECO:0000305}.
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DR EMBL; CM000132; EEC82308.1; -; Genomic_DNA.
DR AlphaFoldDB; B8B7Q4; -.
DR SMR; B8B7Q4; -.
DR STRING; 39946.B8B7Q4; -.
DR EnsemblPlants; BGIOSGA024044-TA; BGIOSGA024044-PA; BGIOSGA024044.
DR Gramene; BGIOSGA024044-TA; BGIOSGA024044-PA; BGIOSGA024044.
DR HOGENOM; CLU_024645_5_0_1; -.
DR OMA; WKLKSIV; -.
DR Proteomes; UP000007015; Chromosome 7.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..356
FT /note="CMP-sialic acid transporter 2"
FT /id="PRO_0000434340"
FT TOPO_DOM 1..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..82
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..149
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 150..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..211
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..277
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..356
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 39477 MW; 3D78AD6BCC5DE2E4 CRC64;
MEYRRVKDQE SYDVVSQKDI ESPGERSLSS TSATSSLSTA GASKGNNSWK LKSIVTLALT
LLTSSQAILI VWSKRAGKYE YSVTTANFSV EALKCLLSLI ALYRTWNSQG VTEDNRLSTS
FDEVSVYPIP AILYMVKNLL QYYIFAYVDA PAYQILKNLN IISTGVLYRI ILKKKLSEIQ
WAAFILLCAG CTTAQLNPSS DHVLQTPIQG WVMAIVMALL SGFAGVYTEA IIKKRPSRNI
NVQNFWLYIF GMLFNLVAIC VQDFDAVMNK GFFHGYSFIT VLMILNHALS GIAVSMVMKY
ADNIVKVYST SVAMLLTAVV SVFLFGFHLS LAFFLGSTVV SVSVYLHSVG KPQPQK
