CSTR2_ORYSJ
ID CSTR2_ORYSJ Reviewed; 356 AA.
AC Q6ZL17; A0A0P0X852;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=CMP-sialic acid transporter 2 {ECO:0000305};
DE Short=CMP-SA-Tr 2 {ECO:0000305};
DE Short=CMP-Sia-Tr 2 {ECO:0000305};
DE AltName: Full=CMP-sialic acid transporter-like protein 2 {ECO:0000303|PubMed:19822337};
DE Short=OsCSTLP2 {ECO:0000303|PubMed:19822337};
GN Name=CSTLP2 {ECO:0000303|PubMed:19822337};
GN OrderedLocusNames=Os07g0573700 {ECO:0000312|EMBL:BAF21983.1},
GN LOC_Os07g38610 {ECO:0000305};
GN ORFNames=OJ1699_E05.21 {ECO:0000312|EMBL:BAC83154.1},
GN OsJ_24829 {ECO:0000312|EMBL:EEE67452.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=19822337; DOI=10.1016/j.phytochem.2009.09.017;
RA Takashima S., Seino J., Nakano T., Fujiyama K., Tsujimoto M., Ishida N.,
RA Hashimoto Y.;
RT "Analysis of CMP-sialic acid transporter-like proteins in plants.";
RL Phytochemistry 70:1973-1981(2009).
CC -!- FUNCTION: Sugar transporter involved in the transport of CMP-sialic
CC acid from the cytoplasm into the Golgi (By similarity). May transport
CC important nucleotide sugars such as CMP-Kdo (2-keto-3-deoxy-D-manno-
CC octulosonic acid) in physiological conditions (PubMed:19822337).
CC {ECO:0000250|UniProtKB:Q654D9, ECO:0000269|PubMed:19822337}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves and stalks.
CC {ECO:0000269|PubMed:19822337}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CMP-
CC Sialate:CMP antiporter (TC 2.A.7.12) subfamily. {ECO:0000305}.
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DR EMBL; AP003845; BAC83154.1; -; Genomic_DNA.
DR EMBL; AP008213; BAF21983.1; -; Genomic_DNA.
DR EMBL; AP014963; BAT02263.1; -; Genomic_DNA.
DR EMBL; CM000144; EEE67452.1; -; Genomic_DNA.
DR EMBL; AK070473; BAG91974.1; -; mRNA.
DR RefSeq; XP_015645198.1; XM_015789712.1.
DR AlphaFoldDB; Q6ZL17; -.
DR SMR; Q6ZL17; -.
DR STRING; 4530.OS07T0573700-01; -.
DR PaxDb; Q6ZL17; -.
DR PRIDE; Q6ZL17; -.
DR EnsemblPlants; Os07t0573700-01; Os07t0573700-01; Os07g0573700.
DR GeneID; 4343687; -.
DR Gramene; Os07t0573700-01; Os07t0573700-01; Os07g0573700.
DR KEGG; osa:4343687; -.
DR eggNOG; KOG2234; Eukaryota.
DR HOGENOM; CLU_024645_5_0_1; -.
DR InParanoid; Q6ZL17; -.
DR OMA; WKLKSIV; -.
DR OrthoDB; 703674at2759; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000007752; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR Genevisible; Q6ZL17; OS.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..356
FT /note="CMP-sialic acid transporter 2"
FT /id="PRO_0000434339"
FT TOPO_DOM 1..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..82
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..149
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 150..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..211
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..277
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..356
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 39491 MW; 8C79FF48BC5F913E CRC64;
MEYRRVKDQE SYDVVSQKDI ESPGERSLSS TSATSSLSTA GASKGKNSWK LKSIVTLALT
LLTSSQAILI VWSKRAGKYE YSVTTANFSV EALKCLLSLI ALYRTWNSQG VTEDNRLSTS
FDEVSVYPIP AILYMVKNLL QYYIFAYVDA PAYQILKNLN IISTGVLYRI ILKKKLSEIQ
WAAFILLCAG CTTAQLNPSS DHVLQTPIQG WVMAIVMALL SGFAGVYTEA IIKKRPSRNI
NVQNFWLYIF GMLFNLVAIC VQDFDAVMNK GFFHGYSFIT VLMILNHALS GIAVSMVMKY
ADNIVKVYST SVAMLLTAVV SVFLFGFHLS LAFFLGSTVV SVSVYLHSVG KPQPQK
