CSTR3_ORYSJ
ID CSTR3_ORYSJ Reviewed; 402 AA.
AC Q5N855; A0A0P0VBM7;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=CMP-sialic acid transporter 3 {ECO:0000305};
DE Short=CMP-SA-Tr 3 {ECO:0000305};
DE Short=CMP-Sia-Tr 3 {ECO:0000305};
DE AltName: Full=CMP-sialic acid transporter-like protein 3 {ECO:0000305};
GN Name=CSTLP3 {ECO:0000305};
GN OrderedLocusNames=Os01g0898900 {ECO:0000312|EMBL:BAF07011.1},
GN LOC_Os01g67330 {ECO:0000305};
GN ORFNames=P0506A10.22 {ECO:0000312|EMBL:BAD82354.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Sugar transporter involved in the transport of CMP-sialic
CC acid from the cytoplasm into the Golgi. May transport important
CC nucleotide sugars such as CMP-Kdo (2-keto-3-deoxy-D-manno-octulosonic
CC acid) in physiological conditions. {ECO:0000250|UniProtKB:Q654D9}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CMP-
CC Sialate:CMP antiporter (TC 2.A.7.12) subfamily. {ECO:0000305}.
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DR EMBL; AP003418; BAD82354.1; -; Genomic_DNA.
DR EMBL; AP008207; BAF07011.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS75728.1; -; Genomic_DNA.
DR EMBL; AK120093; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015621473.1; XM_015765987.1.
DR RefSeq; XP_015621475.1; XM_015765989.1.
DR AlphaFoldDB; Q5N855; -.
DR SMR; Q5N855; -.
DR STRING; 4530.OS01T0898900-01; -.
DR PaxDb; Q5N855; -.
DR PRIDE; Q5N855; -.
DR EnsemblPlants; Os01t0898900-01; Os01t0898900-01; Os01g0898900.
DR GeneID; 4325028; -.
DR Gramene; Os01t0898900-01; Os01t0898900-01; Os01g0898900.
DR KEGG; osa:4325028; -.
DR eggNOG; KOG2234; Eukaryota.
DR HOGENOM; CLU_035460_0_0_1; -.
DR InParanoid; Q5N855; -.
DR OMA; CLYCREN; -.
DR OrthoDB; 754910at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR Genevisible; Q5N855; OS.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..402
FT /note="CMP-sialic acid transporter 3"
FT /id="PRO_0000434341"
FT TOPO_DOM 1..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..73
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..146
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..202
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..280
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 343..402
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT CONFLICT 104..107
FT /note="KPFL -> EPFH (in Ref. 5; AK120093)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 402 AA; 44226 MW; CC629DFE2C95EC62 CRC64;
MSGEVECRVC HAKVQVPMAA AAVSKAYDIH RSSVSSRQRA LNVLLVSGDC VLAGLQPILV
YMCKVDGKFK FSPVSVNFLT EITKIIFAII MLCIQARRLK VGEKPFLTVS TFMQAARNNV
LLAVPALFYA INNYMKFVMQ LYFNPATVKM LGNLKVLVIA VLLKVIMRRR FSTIQWEALA
LLLIGISVNQ LKSLPEGSST LGLPVAAGAY LYTLFFVTVP ALASVYNEKA LKSQFDTSIY
LQNLFLYGYG AIFNFLGLVI TAIIQGPSSF NILEGHSKAT MFLICNNAAQ GILSSFFFKY
ADTILKKYSS TIATIFTGVA SAVLFGHTLT INFVLAISIV IISMHQYLSN QIKDEVPSSK
IEMGDAHEHR SKESVVVNVS DSIATEAKHR HGTDERQPLL PV
