CSTR4_ORYSJ
ID CSTR4_ORYSJ Reviewed; 405 AA.
AC Q7X7C4;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=CMP-sialic acid transporter 4 {ECO:0000305};
DE Short=CMP-SA-Tr 4 {ECO:0000305};
DE Short=CMP-Sia-Tr 4 {ECO:0000305};
DE AltName: Full=CMP-sialic acid transporter-like protein 4 {ECO:0000305};
GN Name=CSTLP4 {ECO:0000305}; OrderedLocusNames=LOC_Os04g41320 {ECO:0000305};
GN ORFNames=OSJNBa0076N16.10 {ECO:0000312|EMBL:CAE02488.2},
GN OSJNBa0084K20.12 {ECO:0000312|EMBL:CAE01663.2};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
CC -!- FUNCTION: Sugar transporter involved in the transport of CMP-sialic
CC acid from the cytoplasm into the Golgi. May transport important
CC nucleotide sugars such as CMP-Kdo (2-keto-3-deoxy-D-manno-octulosonic
CC acid) in physiological conditions. {ECO:0000250|UniProtKB:Q654D9}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CMP-
CC Sialate:CMP antiporter (TC 2.A.7.12) subfamily. {ECO:0000305}.
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DR EMBL; AL606613; CAE01663.2; -; Genomic_DNA.
DR EMBL; AL731617; CAE02488.2; -; Genomic_DNA.
DR EMBL; AP008210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP014960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015636543.1; XM_015781057.1.
DR AlphaFoldDB; Q7X7C4; -.
DR SMR; Q7X7C4; -.
DR STRING; 4530.OS04T0490600-01; -.
DR PaxDb; Q7X7C4; -.
DR GeneID; 4336243; -.
DR KEGG; osa:4336243; -.
DR eggNOG; KOG2234; Eukaryota.
DR InParanoid; Q7X7C4; -.
DR OrthoDB; 754910at2759; -.
DR Proteomes; UP000000763; Chromosome 4.
DR Proteomes; UP000059680; Chromosome 4.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..405
FT /note="CMP-sialic acid transporter 4"
FT /id="PRO_0000434343"
FT TOPO_DOM 1..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..74
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..203
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..281
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..405
FT /note="Lumenal"
FT /evidence="ECO:0000305"
SQ SEQUENCE 405 AA; 44659 MW; 68E3C4B423C88EEF CRC64;
MQRNGVMECS VCHSKVVAPS PRSVSRAYDK HRSKISSKYR ALNFLLVSGD CILVGLQPIL
VFMSKVDGKF QFSPISVNFL TEVTKVIFAI VMLIIQSRKQ KVGEKPLLSL STFVQAARNN
ALLAVPALLY AINNYLKFIM QLYFSPATVK MLSNLKVLVI AILLKFIMRR KFSIIQWEAL
ALLLIGISVN QLSSIPDGTK SFGLAVTTIA YIYTLIFVTV PSLASVYNEY ALKSQFDTSI
YLQNLFLYGY GAIFNFLGIL GTVIFQGPES FDILRGHSRA TMFLICNNAA QGILSSFFFK
YADTILKKYS STVATIFTGL ASAAFLGHTL TVNFLLGISI VFISMHQFFS PLAKVKDDKP
AGALEPEDAQ NHRSSDSSFV NMTAGAADDA SHLTATDERK PLLPI
