ID   CST_CONGE               Reviewed;          29 AA.
AC   P58844;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Geographus scratcher peptide;
OS   Conus geographus (Geography cone) (Nubecula geographus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Gastridium.
OX   NCBI_TaxID=6491;
RN   [1]
RP   PROTEIN SEQUENCE, GAMMA-CARBOXYGLUTAMATION AT GLU-9, AND AMIDATION AT
RP   ASP-29.
RA   Olivera B.M., Johnson D.S., Azimi-Zonooz A., Cruz L.J.;
RT   "Peptides in the venom of the geography cone, Conus geographus.";
RL   (In) Waters D., Lavin M., Maguire D., Pearn J. (eds.);
RL   Toxins and targets, pp.19-28, Harwood Academic Publishers, Melbourne
RL   (1992).
CC   -!- FUNCTION: Causes scratching in mice.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C).
CC   -!- PTM: Contains 2 disulfide bonds (By similarity). They are not added,
CC       since framework XIV presents two different connectivities (I-III, II-IV
CC       and I-IV, II-III). {ECO:0000250}.
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DR   AlphaFoldDB; P58844; -.
DR   ConoServer; 2482; Scratcher peptide.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Gamma-carboxyglutamic acid; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..29
FT                   /note="Geographus scratcher peptide"
FT                   /id="PRO_0000044513"
FT   MOD_RES         9
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         29
FT                   /note="Aspartic acid 1-amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   29 AA;  3265 MW;  296E00CB929C594D CRC64;
     KFLSGGFKEI VCHRYCAKGI AKEFCNCPD