CT027_HUMAN
ID CT027_HUMAN Reviewed; 174 AA.
AC Q9GZN8; A8K4J0; D3DVX8; Q5JX81; Q9NWX3;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=UPF0687 protein C20orf27;
GN Name=C20orf27;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Gastric carcinoma, Teratocarcinoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 2-11 (ISOFORM 1).
RC TISSUE=Platelet;
RX PubMed=12665801; DOI=10.1038/nbt810;
RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R.,
RA Vandekerckhove J.;
RT "Exploring proteomes and analyzing protein processing by mass spectrometric
RT identification of sorted N-terminal peptides.";
RL Nat. Biotechnol. 21:566-569(2003).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9GZN8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9GZN8-2; Sequence=VSP_040293;
CC -!- SIMILARITY: Belongs to the UPF0687 family. {ECO:0000305}.
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DR EMBL; AK000557; BAA91252.1; -; mRNA.
DR EMBL; AK024220; BAB14854.1; -; mRNA.
DR EMBL; AK097645; BAG53501.1; -; mRNA.
DR EMBL; AK290955; BAF83644.1; -; mRNA.
DR EMBL; CR615129; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL109804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10508.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10510.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10511.1; -; Genomic_DNA.
DR EMBL; BC012196; AAH12196.1; -; mRNA.
DR EMBL; BC024036; AAH24036.1; -; mRNA.
DR CCDS; CCDS33436.1; -. [Q9GZN8-2]
DR CCDS; CCDS58763.1; -. [Q9GZN8-1]
DR RefSeq; NP_001034229.1; NM_001039140.2. [Q9GZN8-2]
DR RefSeq; NP_001245358.1; NM_001258429.1. [Q9GZN8-1]
DR RefSeq; NP_001245359.1; NM_001258430.1. [Q9GZN8-1]
DR AlphaFoldDB; Q9GZN8; -.
DR BioGRID; 120312; 31.
DR IntAct; Q9GZN8; 8.
DR MINT; Q9GZN8; -.
DR STRING; 9606.ENSP00000217195; -.
DR iPTMnet; Q9GZN8; -.
DR PhosphoSitePlus; Q9GZN8; -.
DR BioMuta; C20orf27; -.
DR CPTAC; CPTAC-1603; -.
DR EPD; Q9GZN8; -.
DR jPOST; Q9GZN8; -.
DR MassIVE; Q9GZN8; -.
DR MaxQB; Q9GZN8; -.
DR PaxDb; Q9GZN8; -.
DR PeptideAtlas; Q9GZN8; -.
DR PRIDE; Q9GZN8; -.
DR ProteomicsDB; 80100; -. [Q9GZN8-1]
DR ProteomicsDB; 80101; -. [Q9GZN8-2]
DR Antibodypedia; 54581; 49 antibodies from 10 providers.
DR DNASU; 54976; -.
DR Ensembl; ENST00000217195.12; ENSP00000217195.8; ENSG00000101220.18. [Q9GZN8-2]
DR Ensembl; ENST00000379772.4; ENSP00000369097.4; ENSG00000101220.18. [Q9GZN8-1]
DR Ensembl; ENST00000399672.5; ENSP00000382580.1; ENSG00000101220.18. [Q9GZN8-1]
DR GeneID; 54976; -.
DR KEGG; hsa:54976; -.
DR MANE-Select; ENST00000379772.4; ENSP00000369097.4; NM_001258429.2; NP_001245358.1.
DR UCSC; uc002wjh.3; human. [Q9GZN8-1]
DR CTD; 54976; -.
DR DisGeNET; 54976; -.
DR GeneCards; C20orf27; -.
DR HGNC; HGNC:15873; C20orf27.
DR HPA; ENSG00000101220; Low tissue specificity.
DR neXtProt; NX_Q9GZN8; -.
DR OpenTargets; ENSG00000101220; -.
DR PharmGKB; PA25742; -.
DR VEuPathDB; HostDB:ENSG00000101220; -.
DR eggNOG; ENOG502RXJD; Eukaryota.
DR GeneTree; ENSGT00390000008711; -.
DR InParanoid; Q9GZN8; -.
DR OMA; GVRCIGM; -.
DR OrthoDB; 1350523at2759; -.
DR PhylomeDB; Q9GZN8; -.
DR TreeFam; TF323780; -.
DR PathwayCommons; Q9GZN8; -.
DR SignaLink; Q9GZN8; -.
DR BioGRID-ORCS; 54976; 10 hits in 1072 CRISPR screens.
DR ChiTaRS; C20orf27; human.
DR GeneWiki; C20orf27; -.
DR GenomeRNAi; 54976; -.
DR Pharos; Q9GZN8; Tdark.
DR PRO; PR:Q9GZN8; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9GZN8; protein.
DR Bgee; ENSG00000101220; Expressed in nucleus accumbens and 183 other tissues.
DR ExpressionAtlas; Q9GZN8; baseline and differential.
DR Genevisible; Q9GZN8; HS.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IDA:FlyBase.
DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IMP:FlyBase.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IMP:FlyBase.
DR InterPro; IPR026794; UPF0687.
DR PANTHER; PTHR13287; PTHR13287; 1.
DR Pfam; PF15006; DUF4517; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Direct protein sequencing;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..174
FT /note="UPF0687 protein C20orf27"
FT /id="PRO_0000079419"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 147
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9D1K7"
FT VAR_SEQ 6
FT /note="K -> KGKCLPGVVGLAQALPVGPGRRAIAA (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_040293"
FT CONFLICT 14
FT /note="S -> G (in Ref. 1; BAA91252)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 174 AA; 19291 MW; DD114F2C1A7D8B97 CRC64;
MAAANKGNKP RVRSIRFAAG HDAEGSHSHV HFDEKLHDSV VMVTQESDSS FLVKVGFLKI
LHRYEITFTL PPVHRLSKDV REAPVPSLHL KLLSVVPVPE GYSVKCEYSA HKEGVLKEEI
LLACEGGTGT CVRVTVQARV MDRHHGTPML LDGVKCVGAE LEYDSEHSDW HGFD
