CT027_MOUSE
ID CT027_MOUSE Reviewed; 174 AA.
AC Q9D1K7; Q9CVT3;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=UPF0687 protein C20orf27 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-147, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the UPF0687 family. {ECO:0000305}.
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DR EMBL; AK003406; BAB22770.1; -; mRNA.
DR EMBL; BC006041; AAH06041.1; -; mRNA.
DR CCDS; CCDS16756.1; -.
DR RefSeq; NP_080367.1; NM_026091.2.
DR RefSeq; XP_011238047.1; XM_011239745.1.
DR AlphaFoldDB; Q9D1K7; -.
DR BioGRID; 212107; 14.
DR STRING; 10090.ENSMUSP00000099477; -.
DR iPTMnet; Q9D1K7; -.
DR PhosphoSitePlus; Q9D1K7; -.
DR REPRODUCTION-2DPAGE; IPI00133853; -.
DR EPD; Q9D1K7; -.
DR MaxQB; Q9D1K7; -.
DR PaxDb; Q9D1K7; -.
DR PRIDE; Q9D1K7; -.
DR Antibodypedia; 54581; 49 antibodies from 10 providers.
DR Ensembl; ENSMUST00000103188; ENSMUSP00000099477; ENSMUSG00000027327.
DR GeneID; 67326; -.
DR KEGG; mmu:67326; -.
DR UCSC; uc008mks.1; mouse.
DR MGI; MGI:1914576; 1700037H04Rik.
DR VEuPathDB; HostDB:ENSMUSG00000027327; -.
DR eggNOG; ENOG502RXJD; Eukaryota.
DR GeneTree; ENSGT00390000008711; -.
DR HOGENOM; CLU_094626_2_0_1; -.
DR InParanoid; Q9D1K7; -.
DR OMA; GVRCIGM; -.
DR PhylomeDB; Q9D1K7; -.
DR TreeFam; TF323780; -.
DR BioGRID-ORCS; 67326; 5 hits in 74 CRISPR screens.
DR PRO; PR:Q9D1K7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D1K7; protein.
DR Bgee; ENSMUSG00000027327; Expressed in seminiferous tubule of testis and 250 other tissues.
DR ExpressionAtlas; Q9D1K7; baseline and differential.
DR Genevisible; Q9D1K7; MM.
DR GO; GO:0008157; F:protein phosphatase 1 binding; ISO:MGI.
DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISO:MGI.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISO:MGI.
DR InterPro; IPR026794; UPF0687.
DR PANTHER; PTHR13287; PTHR13287; 1.
DR Pfam; PF15006; DUF4517; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9GZN8"
FT CHAIN 2..174
FT /note="UPF0687 protein C20orf27 homolog"
FT /id="PRO_0000079420"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9GZN8"
FT MOD_RES 147
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 174 AA; 19476 MW; 0AB0BF49970C573C CRC64;
MAAANRGSKP RVRSIRFAAG HDAEGSQSHV HFDEKLHDSV VMVTQESDNS FLVKVGFLKI
LHRYEITFTL PPVRRLSKDI RETPVHSLHL KLLSVTPTSE GYSIKCEYSA HKEGVLKEEM
LLACEGDIGT CVRVTVQARV MDRHHGTPML LDGVKCVGAE LEYDSEQSDW LGFD
