ID   CT096_HUMAN             Reviewed;         363 AA.
AC   Q9NUD7; A3KPE0; B2RPH9; Q8N840; Q8NAX5;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Uncharacterized protein C20orf96;
GN   Name=C20orf96;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-305.
RC   TISSUE=Kidney, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PHE-305.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-305.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC03772.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK097394; BAC05033.1; -; mRNA.
DR   EMBL; AK091924; BAC03772.1; ALT_FRAME; mRNA.
DR   EMBL; AL034548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471133; EAX10681.1; -; Genomic_DNA.
DR   EMBL; BC134417; AAI34418.1; -; mRNA.
DR   EMBL; BC137450; AAI37451.1; -; mRNA.
DR   CCDS; CCDS12994.1; -.
DR   RefSeq; NP_542138.1; NM_080571.1.
DR   RefSeq; NP_695001.2; NM_153269.2.
DR   AlphaFoldDB; Q9NUD7; -.
DR   SMR; Q9NUD7; -.
DR   BioGRID; 126645; 17.
DR   IntAct; Q9NUD7; 3.
DR   STRING; 9606.ENSP00000353470; -.
DR   iPTMnet; Q9NUD7; -.
DR   PhosphoSitePlus; Q9NUD7; -.
DR   BioMuta; C20orf96; -.
DR   DMDM; 26392576; -.
DR   EPD; Q9NUD7; -.
DR   MassIVE; Q9NUD7; -.
DR   PaxDb; Q9NUD7; -.
DR   PeptideAtlas; Q9NUD7; -.
DR   PRIDE; Q9NUD7; -.
DR   ProteomicsDB; 82665; -.
DR   Antibodypedia; 62706; 32 antibodies from 9 providers.
DR   DNASU; 140680; -.
DR   Ensembl; ENST00000360321.7; ENSP00000353470.2; ENSG00000196476.12.
DR   GeneID; 140680; -.
DR   KEGG; hsa:140680; -.
DR   MANE-Select; ENST00000360321.7; ENSP00000353470.2; NM_153269.3; NP_695001.2.
DR   UCSC; uc002wde.3; human.
DR   CTD; 140680; -.
DR   DisGeNET; 140680; -.
DR   GeneCards; C20orf96; -.
DR   HGNC; HGNC:16227; C20orf96.
DR   HPA; ENSG00000196476; Low tissue specificity.
DR   neXtProt; NX_Q9NUD7; -.
DR   OpenTargets; ENSG00000196476; -.
DR   PharmGKB; PA25803; -.
DR   VEuPathDB; HostDB:ENSG00000196476; -.
DR   eggNOG; ENOG502S397; Eukaryota.
DR   GeneTree; ENSGT00390000003339; -.
DR   HOGENOM; CLU_065592_0_0_1; -.
DR   InParanoid; Q9NUD7; -.
DR   OMA; CTPDMDI; -.
DR   OrthoDB; 1168106at2759; -.
DR   PhylomeDB; Q9NUD7; -.
DR   TreeFam; TF330721; -.
DR   PathwayCommons; Q9NUD7; -.
DR   SignaLink; Q9NUD7; -.
DR   BioGRID-ORCS; 140680; 15 hits in 1054 CRISPR screens.
DR   ChiTaRS; C20orf96; human.
DR   GenomeRNAi; 140680; -.
DR   Pharos; Q9NUD7; Tdark.
DR   PRO; PR:Q9NUD7; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q9NUD7; protein.
DR   Bgee; ENSG00000196476; Expressed in right uterine tube and 95 other tissues.
DR   ExpressionAtlas; Q9NUD7; baseline and differential.
DR   Genevisible; Q9NUD7; HS.
DR   InterPro; IPR029236; DUF4618.
DR   PANTHER; PTHR28574; PTHR28574; 1.
DR   Pfam; PF15397; DUF4618; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..363
FT                   /note="Uncharacterized protein C20orf96"
FT                   /id="PRO_0000079450"
FT   COILED          109..329
FT                   /evidence="ECO:0000255"
FT   VARIANT         305
FT                   /note="I -> F (in dbSNP:rs3827147)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT                   /id="VAR_056847"
SQ   SEQUENCE   363 AA;  42859 MW;  0B1A597E972A7EAD CRC64;
     MAHVLQKPKH SGTHSIVQEF QVPDYVPWQQ SKQETKPSTL PPVQQANSLH TSKMKTLTRV
     QPVFHFKPTT VVTSCQPKNP RELHRRRKLD PGKMHAKIWL MKTSLRSGRA ALRELRSREN
     FLSKLNRELI ETIQEMENST TLHVRALLQQ QDTLATIIDI LEYSNKKRLQ QLKSELQEWE
     EKKKCKMSYL EQQAEQLNAK IEKTQEEVNF LSTYMDHEYS IKSVQISTLM RQLQQVKDSQ
     QDELDDLGEM RRKVLESLSD KIQKKKKKIL SSVVAETQRP YEEALLQKMW ESQDFLKCMQ
     RFREIIDQFE ENMPVLRAEV EELQAQTREP REVIFEDVLL RRPKCTPDMD VILNIPVEEP
     LPF