ID   CT112_LACTA             Reviewed;         129 AA.
AC   P0CAZ5;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=M-zodatoxin-Lt8l;
DE            Short=M-ZDTX-Lt8l;
DE   AltName: Full=Cytoinsectotoxin 1-12;
DE   Flags: Precursor;
GN   Name=cit 1-12;
OS   Lachesana tarabaevi (Spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Entelegynae incertae sedis; Zodariidae;
OC   Lachesana.
OX   NCBI_TaxID=379576;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18215128; DOI=10.1042/bj20071123;
RA   Vassilevski A.A., Kozlov S.A., Samsonova O.V., Egorova N.S., Karpunin D.V.,
RA   Pluzhnikov K.A., Feofanov A.V., Grishin E.V.;
RT   "Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides
RT   from spider venom.";
RL   Biochem. J. 411:687-696(2008).
CC   -!- FUNCTION: Insecticidal, cytolytic and antimicrobial peptide. Forms
CC       voltage-dependent, ion-permeable channels in membranes. At high
CC       concentration causes cell membrane lysis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the cationic peptide 06 (cytoinsectotoxin)
CC       family. {ECO:0000305}.
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DR   ArachnoServer; AS000766; M-zodatoxin-Lt8l.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cytolysis; Hemolysis; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..60
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000380143"
FT   CHAIN           61..129
FT                   /note="M-zodatoxin-Lt8l"
FT                   /id="PRO_0000380144"
SQ   SEQUENCE   129 AA;  14584 MW;  42782EC1FE4244CB CRC64;
     MKYFVVXXAL VAAFACIAES KPAESEHELA EVEEENELAD LEDAVWLEDL ADLSDLEETR
     GFFGNAWKKI KGKAEKFFRK KAAKIIAKKE GITKEEAEAK VDPMSKKQIK VYLLKHYGKK
     ALQKASEKL