ID   CT11_CONAA              Reviewed;          64 AA.
AC   A0A3G3C7S2;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   13-FEB-2019, sequence version 1.
DT   03-AUG-2022, entry version 13.
DE   RecName: Full=Conotoxin Am1.1 {ECO:0000305};
DE   Flags: Precursor;
OS   Conus amadis (Amadis cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Leptoconus.
OX   NCBI_TaxID=198732;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 50-64, SUBCELLULAR
RP   LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, AND HYDROXYLATION AT PRO-60.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30593932; DOI=10.1016/j.jprot.2018.12.028;
RA   Vijayasarathy M., Balaram P.;
RT   "Cone snail prolyl-4-hydroxylase alpha-subunit sequences derived from
RT   transcriptomic data and mass spectrometric analysis of variable proline
RT   hydroxylation in C. amadis venom.";
RL   J. Proteomics 194:37-48(2019).
CC   -!- FUNCTION: Probable toxin that inhibits ion channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30593932}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30593932}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/2 pattern.
CC       {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; MH282813; AYP73020.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation;
KW   Ion channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..49
FT                   /evidence="ECO:0000305|PubMed:30593932"
FT                   /id="PRO_0000453594"
FT   PEPTIDE         50..64
FT                   /note="Conotoxin Am1.1"
FT                   /evidence="ECO:0000269|PubMed:30593932"
FT                   /id="PRO_5028504155"
FT   MOD_RES         60
FT                   /note="4-hydroxyproline; partial; in major form"
FT                   /evidence="ECO:0000269|PubMed:30593932"
SQ   SEQUENCE   64 AA;  6890 MW;  10EC803DFB8DB7D4 CRC64;
     MSCLPVFVIL LLLTASGPSV DARLKTKDDV PLSSFRDNAK STLRRLQDKS ACCGYKLCSP
     CGQA