ID   CT12_CONLE              Reviewed;          58 AA.
AC   P0C907;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Conotoxin Leo-T2 {ECO:0000303|PubMed:18221274};
DE   Flags: Precursor;
OS   Conus leopardus (Leopard cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lithoconus.
OX   NCBI_TaxID=101306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18221274; DOI=10.1111/j.1365-294x.2007.03627.x;
RA   Remigio E.A., Duda T.F. Jr.;
RT   "Evolution of ecological specialization and venom of a predatory marine
RT   gastropod.";
RL   Mol. Ecol. 17:1156-1162(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:18221274}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:18221274}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; EF467315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0C907; -.
DR   ConoServer; 3015; Lp5.4 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..47
FT                   /evidence="ECO:0000305|PubMed:18221274"
FT                   /id="PRO_0000368014"
FT   PEPTIDE         48..57
FT                   /note="Conotoxin Leo-T2"
FT                   /evidence="ECO:0000305|PubMed:18221274"
FT                   /id="PRO_0000368015"
SQ   SEQUENCE   58 AA;  6505 MW;  69C235465996C6A3 CRC64;
     MRCLPVFIIL PLLIPSAPSV DAQPMTEDDV PLASFHEQTL QELWNKRPCC PLIPGCCR