ID   CT12_RANCI              Reviewed;          16 AA.
AC   P81840; P81841; P81842; P81843;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Citropin-1.2;
DE   Contains:
DE     RecName: Full=Citropin-1.2.1;
DE   Contains:
DE     RecName: Full=Citropin-1.2.2;
DE   Contains:
DE     RecName: Full=Citropin-1.2.3;
OS   Ranoidea citropa (Australian Blue Mountains tree frog) (Litoria citropa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Ranoidea.
OX   NCBI_TaxID=94770;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT LEU-16.
RC   TISSUE=Skin secretion;
RX   PubMed=10504394; DOI=10.1046/j.1432-1327.1999.00750.x;
RA   Wegener K.L., Wabnitz P.A., Carver J.A., Bowie J.H., Chia B.C.S.,
RA   Wallace J.C., Tyler M.J.;
RT   "Host defence peptides from the skin glands of the Australian blue
RT   mountains tree-frog Litoria citropa. Solution structure of the
RT   antibacterial peptide citropin 1.1.";
RL   Eur. J. Biochem. 265:627-637(1999).
CC   -!- FUNCTION: Bacteriostatic action for Gram-positive bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the dorsal and submental skin glands.
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DR   AlphaFoldDB; P81840; -.
DR   TCDB; 1.C.76.1.4; the pore-forming maculatin peptide (maculatin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR013157; Aurein_antimicrobial_peptide.
DR   Pfam; PF08256; Antimicrobial20; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..16
FT                   /note="Citropin-1.2"
FT                   /id="PRO_0000010193"
FT   PEPTIDE         1..11
FT                   /note="Citropin-1.2.3"
FT                   /id="PRO_0000010194"
FT   PEPTIDE         3..14
FT                   /note="Citropin-1.2.1"
FT                   /id="PRO_0000010195"
FT   PEPTIDE         4..14
FT                   /note="Citropin-1.2.2"
FT                   /id="PRO_0000010196"
FT   MOD_RES         16
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:10504394"
SQ   SEQUENCE   16 AA;  1616 MW;  1D878515ABD73DE9 CRC64;
     GLFDIIKKVA SVVGGL