ID   CT13_CONCL              Reviewed;          65 AA.
AC   D2Y173; D6C4H7;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Conotoxin Cal1.3 {ECO:0000305};
DE   AltName: Full=Conotoxin Cal1.1a {ECO:0000303|PubMed:21172372};
DE   AltName: Full=Conotoxin Cl1.3 {ECO:0000303|PubMed:20363338};
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA   Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA   Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA   Olivera B.M.;
RT   "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT   1844.";
RL   Mol. Phylogenet. Evol. 56:1-12(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT CYS-62.
RC   TISSUE=Venom duct;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The cysteine framework is X (CC-CX[hydroxyPro]C).
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; FJ959119; ADB93089.1; -; Genomic_DNA.
DR   EMBL; GU290203; ADB43130.1; -; mRNA.
DR   AlphaFoldDB; D2Y173; -.
DR   ConoServer; 4005; Cal1.3 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Disulfide bond; Hydroxylation; Ion channel impairing toxin;
KW   Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..49
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000566291"
FT   PEPTIDE         52..62
FT                   /note="Conotoxin Cal1.3"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000566292"
FT   MOD_RES         61
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         62
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT   DISULFID        52..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..59
FT                   /evidence="ECO:0000250"
FT   CONFLICT        55
FT                   /note="R -> K (in Ref. 1; ADB93089)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   65 AA;  7311 MW;  1E3C2AA5C6B55D73 CRC64;
     MRCLPVFIIL LLLASTAAVD VAGSKLKRRL ERKPYQGSQA YVKKTAFGLR KCCKRHHGCH
     PCGRK