CT141_HUMAN
ID CT141_HUMAN Reviewed; 165 AA.
AC Q9NUB4;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Uncharacterized protein C20orf141;
GN Name=C20orf141;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NUB4; P02649: APOE; NbExp=3; IntAct=EBI-9088162, EBI-1222467;
CC Q9NUB4; P54253: ATXN1; NbExp=3; IntAct=EBI-9088162, EBI-930964;
CC Q9NUB4; P42858: HTT; NbExp=6; IntAct=EBI-9088162, EBI-466029;
CC Q9NUB4; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-9088162, EBI-1055254;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL713708; CAD28505.1; -; mRNA.
DR EMBL; AL035460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC014591; AAH14591.1; -; mRNA.
DR CCDS; CCDS13034.1; -.
DR RefSeq; NP_001243467.1; NM_001256538.1.
DR RefSeq; NP_542777.1; NM_080739.2.
DR AlphaFoldDB; Q9NUB4; -.
DR BioGRID; 126141; 19.
DR IntAct; Q9NUB4; 5.
DR BioMuta; C20orf141; -.
DR DMDM; 27734259; -.
DR MassIVE; Q9NUB4; -.
DR PaxDb; Q9NUB4; -.
DR PeptideAtlas; Q9NUB4; -.
DR PRIDE; Q9NUB4; -.
DR Antibodypedia; 54290; 75 antibodies from 13 providers.
DR DNASU; 128653; -.
DR Ensembl; ENST00000380589.4; ENSP00000369963.3; ENSG00000258713.3.
DR Ensembl; ENST00000603872.2; ENSP00000473907.1; ENSG00000258713.3.
DR GeneID; 128653; -.
DR KEGG; hsa:128653; -.
DR MANE-Select; ENST00000603872.2; ENSP00000473907.1; NM_001256538.2; NP_001243467.1.
DR UCSC; uc002wgw.4; human.
DR CTD; 128653; -.
DR GeneCards; C20orf141; -.
DR HGNC; HGNC:16134; C20orf141.
DR HPA; ENSG00000258713; Tissue enriched (testis).
DR neXtProt; NX_Q9NUB4; -.
DR OpenTargets; ENSG00000258713; -.
DR PharmGKB; PA25684; -.
DR VEuPathDB; HostDB:ENSG00000258713; -.
DR eggNOG; ENOG502RU2X; Eukaryota.
DR GeneTree; ENSGT00910000144368; -.
DR HOGENOM; CLU_136858_0_0_1; -.
DR InParanoid; Q9NUB4; -.
DR OMA; HTHLTRG; -.
DR OrthoDB; 1605484at2759; -.
DR PhylomeDB; Q9NUB4; -.
DR PathwayCommons; Q9NUB4; -.
DR SignaLink; Q9NUB4; -.
DR BioGRID-ORCS; 128653; 6 hits in 1037 CRISPR screens.
DR GenomeRNAi; 128653; -.
DR Pharos; Q9NUB4; Tdark.
DR PRO; PR:Q9NUB4; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9NUB4; protein.
DR Bgee; ENSG00000258713; Expressed in left testis and 44 other tissues.
DR Genevisible; Q9NUB4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR040425; C20orf141-like.
DR PANTHER; PTHR39222; PTHR39222; 1.
DR Pfam; PF17717; DUF5562; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..165
FT /note="Uncharacterized protein C20orf141"
FT /id="PRO_0000079466"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 165 AA; 17394 MW; B7F7FF37EEA6B361 CRC64;
MTRLCLPRPE AREDPIPVPP RGLGAGEGSG SPVRPPVSTW GPSWAQLLDS VLWLGALGLT
IQAVFSTTGP ALLLLLVSFL TFDLLHRPAG HTLPQRKLLT RGQSQGAGEG PGQQEALLLQ
MGTVSGQLSL QDALLLLLMG LGPLLRACGM PLTLLGLAFC LHPWA
