CT173_HUMAN
ID CT173_HUMAN Reviewed; 149 AA.
AC Q96LM9; A6PVJ1; Q2M293; Q5JWS4; Q9H449;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Uncharacterized protein C20orf173;
GN Name=C20orf173;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP GLU-141.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96LM9; O14964: HGS; NbExp=3; IntAct=EBI-12851858, EBI-740220;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96LM9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96LM9-2; Sequence=VSP_040891;
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DR EMBL; AK058089; BAB71659.1; -; mRNA.
DR EMBL; AK310337; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL121586; CAO03347.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW76202.1; -; Genomic_DNA.
DR EMBL; BC112060; AAI12061.1; -; mRNA.
DR EMBL; BC112062; AAI12063.1; -; mRNA.
DR CCDS; CCDS46594.1; -. [Q96LM9-2]
DR RefSeq; NP_001138822.1; NM_001145350.1. [Q96LM9-2]
DR AlphaFoldDB; Q96LM9; -.
DR BioGRID; 126744; 1.
DR IntAct; Q96LM9; 1.
DR BioMuta; C20orf173; -.
DR PaxDb; Q96LM9; -.
DR PeptideAtlas; Q96LM9; -.
DR PRIDE; Q96LM9; -.
DR TopDownProteomics; Q96LM9-1; -. [Q96LM9-1]
DR Antibodypedia; 54916; 80 antibodies from 13 providers.
DR DNASU; 140873; -.
DR Ensembl; ENST00000246199.5; ENSP00000246199.2; ENSG00000125975.14. [Q96LM9-1]
DR Ensembl; ENST00000374345.8; ENSP00000363465.4; ENSG00000125975.14. [Q96LM9-2]
DR Ensembl; ENST00000444723.3; ENSP00000403566.1; ENSG00000125975.14. [Q96LM9-2]
DR GeneID; 140873; -.
DR KEGG; hsa:140873; -.
DR MANE-Select; ENST00000444723.3; ENSP00000403566.1; NM_001145350.2; NP_001138822.1. [Q96LM9-2]
DR UCSC; uc002xcp.3; human. [Q96LM9-1]
DR CTD; 140873; -.
DR DisGeNET; 140873; -.
DR GeneCards; C20orf173; -.
DR HGNC; HGNC:16166; C20orf173.
DR HPA; ENSG00000125975; Tissue enriched (testis).
DR neXtProt; NX_Q96LM9; -.
DR PharmGKB; PA25716; -.
DR VEuPathDB; HostDB:ENSG00000125975; -.
DR eggNOG; KOG2692; Eukaryota.
DR GeneTree; ENSGT00510000049503; -.
DR HOGENOM; CLU_072229_0_0_1; -.
DR InParanoid; Q96LM9; -.
DR OMA; LWLMAPC; -.
DR OrthoDB; 1208125at2759; -.
DR PhylomeDB; Q96LM9; -.
DR TreeFam; TF342353; -.
DR PathwayCommons; Q96LM9; -.
DR SignaLink; Q96LM9; -.
DR BioGRID-ORCS; 140873; 14 hits in 1051 CRISPR screens.
DR ChiTaRS; C20orf173; human.
DR GenomeRNAi; 140873; -.
DR Pharos; Q96LM9; Tdark.
DR PRO; PR:Q96LM9; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q96LM9; protein.
DR Bgee; ENSG00000125975; Expressed in right testis and 21 other tissues.
DR ExpressionAtlas; Q96LM9; baseline and differential.
DR Genevisible; Q96LM9; HS.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0010706; P:ganglioside biosynthetic process via lactosylceramide; IBA:GO_Central.
DR Gene3D; 3.90.1480.20; -; 1.
DR InterPro; IPR038578; GT29-like_sf.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..149
FT /note="Uncharacterized protein C20orf173"
FT /id="PRO_0000079483"
FT VAR_SEQ 1..50
FT /note="MLSGPHPSPTFRPNPCPWPCLHSLWMEISPTQLCFLSPGPSPQSPSCCFQ
FT -> MKRWQIFVLWVFWVLILWLMTPYLDLTPESAPQEKRMYLVPQHCDCPWFSSGKCGC
FT PSETLNCSSCHHTADEWNWLDACSRKTMGYLMRTRESMTSDTVLWWL (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_040891"
FT VARIANT 141
FT /note="K -> E (in dbSNP:rs7261862)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_024334"
SQ SEQUENCE 149 AA; 16552 MW; CB1080296B7486B9 CRC64;
MLSGPHPSPT FRPNPCPWPC LHSLWMEISP TQLCFLSPGP SPQSPSCCFQ GMNSGSELGK
LWRKLFKGIP RLSVSHFDFY CGTCVLLGRP QIPQGSSLGN DIDQYPVVFR NASDQGSWMQ
LEMLLRKLSD LVWTSDALSD KILEDGLVP
