ID   CT1AA_BACTM             Reviewed;         249 AA.
AC   P0A383; P05069; P05628;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Type-1Aa cytolytic delta-endotoxin;
DE   AltName: Full=27 kDa cytolytic toxin;
GN   Name=cyt1Aa; Synonyms=cytA;
OS   Bacillus thuringiensis subsp. morrisoni.
OG   Plasmid 72 Kb.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PG14;
RX   PubMed=3575104; DOI=10.1093/nar/15.8.3619;
RA   Earp D.J., Ellar D.J.;
RT   "Bacillus thuringiensis var. morrisoni strain PG14: nucleotide sequence of
RT   a gene encoding a 27kDa crystal protein.";
RL   Nucleic Acids Res. 15:3619-3619(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PG14;
RA   Galjart N.J., Sivasubramanian N., Federici B.A.;
RT   "Plasmid location, cloning, and sequence analysis of the gene encoding a
RT   27.3-kilodalton cytolytic protein from Bacillus thuringiensis subsp.
RT   morrisoni (PG-14).";
RL   Curr. Microbiol. 16:171-177(1987).
CC   -!- FUNCTION: Kills the larvae of dipteran insects by making pores in the
CC       epithelial cell membrane of the insect midgut. Acts on mosquitos and
CC       black flies.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- PTM: Active after proteolytic processing.
CC   -!- SIMILARITY: Belongs to the cyt1/cyt2 endotoxin family. {ECO:0000305}.
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DR   EMBL; Y00135; CAA68329.1; -; Genomic_DNA.
DR   EMBL; M35968; AAA22553.1; -; Genomic_DNA.
DR   PIR; A27520; A27520.
DR   AlphaFoldDB; P0A383; -.
DR   SMR; P0A383; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.198.10; -; 1.
DR   InterPro; IPR035918; CytB_endotoxin-like_sf.
DR   InterPro; IPR001615; Endotoxin_CytB.
DR   Pfam; PF01338; Bac_thur_toxin; 1.
DR   SUPFAM; SSF55676; SSF55676; 1.
PE   2: Evidence at transcript level;
KW   Plasmid; Sporulation; Toxin; Virulence.
FT   CHAIN           1..249
FT                   /note="Type-1Aa cytolytic delta-endotoxin"
FT                   /id="PRO_0000174105"
SQ   SEQUENCE   249 AA;  27315 MW;  F37C3F06DDC7DD81 CRC64;
     MENLNHCPLE DIKVNPWKTP QSTARVITLR VEDPNEINNL LSINEIDNPN YILQAIMLAN
     AFQNALVPTS TDFGDALRFS MAKGLEIANT ITPMGAVVSY VDQNVTQTNN QVSVMINKVL
     EVLKTVLGVA LSGSVIDQLT AAVTNTFTNL NTQKNEAWIF WGKETANQTN YTYNVLFAIQ
     NAQTGGVMYC VPVGFEIKVS AVKEQVLFFT IQDSASYNVN IQSLKFAQPL VSSSQYPIAD
     LTSAINGTL