ID   CT1AB_BACTV             Reviewed;         250 AA.
AC   P94594;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Type-1Ab cytolytic delta-endotoxin;
DE   AltName: Full=27 kDa cytolytic toxin;
GN   Name=cyt1Ab1;
OS   Bacillus thuringiensis subsp. medellin.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=79672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H30 / 163-131;
RX   PubMed=9023925; DOI=10.1128/aem.63.2.468-473.1997;
RA   Thiery I., Delecluse A., Tamayo M.C., Orduz S.;
RT   "Identification of a gene for Cyt1A-like hemolysin from Bacillus
RT   thuringiensis subsp. medellin and expression in a crystal-negative B.
RT   thuringiensis strain.";
RL   Appl. Environ. Microbiol. 63:468-473(1997).
CC   -!- FUNCTION: Kills the larvae of dipteran insects by making pores in the
CC       epithelial cell membrane of the insect midgut.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- PTM: Active after proteolytic processing.
CC   -!- SIMILARITY: Belongs to the cyt1/cyt2 endotoxin family. {ECO:0000305}.
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DR   EMBL; X98793; CAA67328.1; -; Genomic_DNA.
DR   AlphaFoldDB; P94594; -.
DR   SMR; P94594; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.198.10; -; 1.
DR   InterPro; IPR035918; CytB_endotoxin-like_sf.
DR   InterPro; IPR001615; Endotoxin_CytB.
DR   Pfam; PF01338; Bac_thur_toxin; 1.
DR   SUPFAM; SSF55676; SSF55676; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..250
FT                   /note="Type-1Ab cytolytic delta-endotoxin"
FT                   /id="PRO_0000174106"
SQ   SEQUENCE   250 AA;  27507 MW;  A57464B0E2C7AEF6 CRC64;
     MENPNHCPLE DIQVNPWKTP QSKARVITLR IDDPNEINNL LSINEIENTN YLLQAIMLAN
     AFQKALVPTS TEFAEDALQF SMTKGLEVAN TISPPGAVVQ YVDQNVSQTN NQVSAMINKV
     LDVLKSILGV ALGQSVIEQL TSAVTNTFTN LNTQKNEAWI FWGRETSTQT NYTYNVLFAI
     QNGQTGGVMY CVPVGFEIKV SAVKERVLFL TIQDSASYNV NIQSLKFAQP LVSASEYPIA
     DLTSAINGTL