ID   CT243_CONLT             Reviewed;          63 AA.
AC   Q3YEH0;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Conotoxin LeDr243 {ECO:0000303|PubMed:16999774};
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16999774; DOI=10.1111/j.1747-0285.2006.00422.x;
RA   Luo S., Zhangsun D., Wu Y., Zhu X., Xie L., Hu Y., Zhang J., Zhao X.;
RT   "Identification and molecular diversity of T-superfamily conotoxins from
RT   Conus lividus and Conus litteratus.";
RL   Chem. Biol. Drug Des. 68:97-106(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC).
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; DQ141143; AAZ85408.1; -; mRNA.
DR   AlphaFoldDB; Q3YEH0; -.
DR   ConoServer; 1680; Lt5.2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..47
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000274068"
FT   PEPTIDE         50..60
FT                   /note="Conotoxin LeDr243"
FT                   /id="PRO_0000274069"
FT   PROPEP          62..63
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000274070"
FT   MOD_RES         60
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  6915 MW;  156F26FFF9EF541B CRC64;
     MRCLPVFVIL LLLIASTPSI DARPKTKDDM PLASFNDNAK RILQILSRKP CCSIHDNSCC
     GLG