ID   CT2BB_BACTJ             Reviewed;         263 AA.
AC   O32322;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Type-2Bb cytolytic delta-endotoxin;
DE   AltName: Full=30 kDa cytolytic toxin;
GN   Name=cyt2Bb1;
OS   Bacillus thuringiensis subsp. jegathesan.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=56955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=9251213; DOI=10.1128/aem.63.8.3254-3260.1997;
RA   Cheong H., Gill S.S.;
RT   "Cloning and characterization of a cytolytic and mosquitocidal delta-
RT   endotoxin from Bacillus thuringiensis subsp. jegathesan.";
RL   Appl. Environ. Microbiol. 63:3254-3260(1997).
CC   -!- FUNCTION: Kills the larvae of dipteran insects by making pores in the
CC       epithelial cell membrane of the insect midgut. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- PTM: Active after proteolytic processing. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cyt1/cyt2 endotoxin family. {ECO:0000305}.
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DR   EMBL; U82519; AAB93477.1; -; Genomic_DNA.
DR   AlphaFoldDB; O32322; -.
DR   SMR; O32322; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.198.10; -; 1.
DR   InterPro; IPR035918; CytB_endotoxin-like_sf.
DR   InterPro; IPR001615; Endotoxin_CytB.
DR   Pfam; PF01338; Bac_thur_toxin; 1.
DR   SUPFAM; SSF55676; SSF55676; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Sporulation; Toxin; Virulence.
FT   CHAIN           1..263
FT                   /note="Type-2Bb cytolytic delta-endotoxin"
FT                   /id="PRO_0000174110"
SQ   SEQUENCE   263 AA;  30059 MW;  BDB7B72CDE090D9D CRC64;
     MYTKNLNSLE INEDYQYSRP IIKKPFRHIT LTVPSSDIAS FNEIFYLEPQ YVAQALRLTN
     TFQAAIDPLT LNFDFEKALQ IANGLPNAGI TGTLNQSVIQ QTIEISVMIS QIKEIIRNVL
     GLVINSTNFW NSVLAAITNT FTNLEPQVDE NWIVWRNLSA THTSYYYKIL FSIQNEDTGA
     FMAVLPIAFE ITVDVQKQQL LFITIRDSAR YEVKMKALTV VQLLDSYNAP IIDVFNVHNY
     GLYQSNHPNH HILQNLNLNK IKG