CT451_HUMAN
ID CT451_HUMAN Reviewed; 189 AA.
AC Q5HYN5; B9EIR8;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Cancer/testis antigen family 45 member A1 {ECO:0000312|HGNC:HGNC:33267};
DE AltName: Full=Cancer/testis antigen 45-1 {ECO:0000303|PubMed:15905330};
DE AltName: Full=Cancer/testis antigen 45A1 {ECO:0000305};
GN Name=CT45A1 {ECO:0000312|HGNC:HGNC:33267};
GN Synonyms=CT45-1 {ECO:0000303|PubMed:15905330};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND IDENTIFICATION AS A
RP CANCER/TESTIS ANTIGEN.
RX PubMed=15905330; DOI=10.1073/pnas.0502583102;
RA Chen Y.-T., Scanlan M.J., Venditti C.A., Chua R., Theiler G.,
RA Stevenson B.J., Iseli C., Gure A.O., Vasicek T., Strausberg R.L.,
RA Jongeneel C.V., Old L.J., Simpson A.J.G.;
RT "Identification of cancer/testis-antigen genes by massively parallel
RT signature sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:7940-7945(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5HYN5; Q16548: BCL2A1; NbExp=3; IntAct=EBI-12051833, EBI-1003550;
CC Q5HYN5; Q16543: CDC37; NbExp=3; IntAct=EBI-12051833, EBI-295634;
CC Q5HYN5; P61024: CKS1B; NbExp=3; IntAct=EBI-12051833, EBI-456371;
CC Q5HYN5; P68400: CSNK2A1; NbExp=3; IntAct=EBI-12051833, EBI-347804;
CC Q5HYN5; P0DMU9: CT45A10; NbExp=3; IntAct=EBI-12051833, EBI-12153495;
CC Q5HYN5; Q8N9E0: FAM133A; NbExp=3; IntAct=EBI-12051833, EBI-10268158;
CC Q5HYN5; P61328-2: FGF12; NbExp=3; IntAct=EBI-12051833, EBI-10699759;
CC Q5HYN5; O95995: GAS8; NbExp=3; IntAct=EBI-12051833, EBI-1052570;
CC Q5HYN5; Q8N8X9: MAB21L3; NbExp=3; IntAct=EBI-12051833, EBI-10268010;
CC Q5HYN5; Q9BU76: MMTAG2; NbExp=3; IntAct=EBI-12051833, EBI-742459;
CC Q5HYN5; Q6ZUT1: NKAPD1; NbExp=3; IntAct=EBI-12051833, EBI-3920396;
CC Q5HYN5; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12051833, EBI-741158;
CC Q5HYN5; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-12051833, EBI-5280197;
CC Q5HYN5; Q2KHN1: RNF151; NbExp=3; IntAct=EBI-12051833, EBI-12002474;
CC Q5HYN5; P35268: RPL22; NbExp=3; IntAct=EBI-12051833, EBI-354533;
CC Q5HYN5; O00560: SDCBP; NbExp=3; IntAct=EBI-12051833, EBI-727004;
CC Q5HYN5; Q9H190: SDCBP2; NbExp=3; IntAct=EBI-12051833, EBI-742426;
CC Q5HYN5; Q8N9Q2: SREK1IP1; NbExp=3; IntAct=EBI-12051833, EBI-10268630;
CC -!- TISSUE SPECIFICITY: Testis specific. Expressed in cancer cell lines.
CC {ECO:0000269|PubMed:15905330}.
CC -!- SIMILARITY: Belongs to the CT45 family.
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DR EMBL; AY743709; AAW66464.1; -; mRNA.
DR EMBL; AC240442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140913; AAI40914.1; -; mRNA.
DR CCDS; CCDS48174.1; -.
DR RefSeq; NP_001017417.1; NM_001017417.2.
DR RefSeq; XP_005278198.1; XM_005278141.3.
DR RefSeq; XP_011529654.1; XM_011531352.1.
DR RefSeq; XP_016855470.1; XM_016999981.1.
DR RefSeq; XP_016855471.1; XM_016999982.1.
DR RefSeq; XP_016855472.1; XM_016999983.1.
DR RefSeq; XP_016855473.1; XM_016999984.1.
DR AlphaFoldDB; Q5HYN5; -.
DR SMR; Q5HYN5; -.
DR BioGRID; 139069; 22.
DR IntAct; Q5HYN5; 18.
DR STRING; 9606.ENSP00000470185; -.
DR GlyGen; Q5HYN5; 1 site.
DR iPTMnet; Q5HYN5; -.
DR PhosphoSitePlus; Q5HYN5; -.
DR BioMuta; CT45A1; -.
DR DMDM; 74741538; -.
DR EPD; Q5HYN5; -.
DR jPOST; Q5HYN5; -.
DR MassIVE; Q5HYN5; -.
DR MaxQB; Q5HYN5; -.
DR PaxDb; Q5HYN5; -.
DR PeptideAtlas; Q5HYN5; -.
DR PRIDE; Q5HYN5; -.
DR Antibodypedia; 72363; 57 antibodies from 16 providers.
DR DNASU; 541466; -.
DR Ensembl; ENST00000594117.4; ENSP00000470185.2; ENSG00000268940.6.
DR Ensembl; ENST00000594565.6; ENSP00000472303.1; ENSG00000268940.6.
DR GeneID; 541466; -.
DR KEGG; hsa:541466; -.
DR MANE-Select; ENST00000594565.6; ENSP00000472303.1; NM_001017417.3; NP_001017417.1.
DR UCSC; uc033ewc.1; human.
DR CTD; 541466; -.
DR DisGeNET; 541466; -.
DR GeneCards; CT45A1; -.
DR HGNC; HGNC:33267; CT45A1.
DR HPA; ENSG00000268940; Tissue enriched (testis).
DR MIM; 300648; gene.
DR neXtProt; NX_Q5HYN5; -.
DR OpenTargets; ENSG00000268940; -.
DR PharmGKB; PA164718185; -.
DR VEuPathDB; HostDB:ENSG00000268940; -.
DR eggNOG; KOG3768; Eukaryota.
DR GeneTree; ENSGT00390000016655; -.
DR HOGENOM; CLU_123664_0_0_1; -.
DR InParanoid; Q5HYN5; -.
DR OMA; IVNIKRM; -.
DR OrthoDB; 1187027at2759; -.
DR PhylomeDB; Q5HYN5; -.
DR PathwayCommons; Q5HYN5; -.
DR SignaLink; Q5HYN5; -.
DR BioGRID-ORCS; 541466; 12 hits in 199 CRISPR screens.
DR GenomeRNAi; 541466; -.
DR Pharos; Q5HYN5; Tbio.
DR PRO; PR:Q5HYN5; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5HYN5; protein.
DR Bgee; ENSG00000268940; Expressed in right testis and 45 other tissues.
DR Genevisible; Q5HYN5; HS.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR029307; INT_SG_DDX_CT_C.
DR Pfam; PF15300; INT_SG_DDX_CT_C; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..189
FT /note="Cancer/testis antigen family 45 member A1"
FT /id="PRO_0000308946"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 189 AA; 21273 MW; 3F92AC9CB3C2F396 CRC64;
MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKAKKLMT
GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQR
EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH
LKKKLKRMI
