CT452_HUMAN
ID CT452_HUMAN Reviewed; 189 AA.
AC Q5DJT8; Q5JRH3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2015, sequence version 3.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Cancer/testis antigen family 45 member A2 {ECO:0000312|HGNC:HGNC:28400};
DE AltName: Full=Cancer/testis antigen 45-2 {ECO:0000303|PubMed:15905330};
DE AltName: Full=Cancer/testis antigen 45A2 {ECO:0000305};
GN Name=CT45A2 {ECO:0000312|HGNC:HGNC:28400};
GN Synonyms=CT45-2 {ECO:0000303|PubMed:15905330};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND IDENTIFICATION AS A
RP CANCER/TESTIS ANTIGEN.
RX PubMed=15905330; DOI=10.1073/pnas.0502583102;
RA Chen Y.-T., Scanlan M.J., Venditti C.A., Chua R., Theiler G.,
RA Stevenson B.J., Iseli C., Gure A.O., Vasicek T., Strausberg R.L.,
RA Jongeneel C.V., Old L.J., Simpson A.J.G.;
RT "Identification of cancer/testis-antigen genes by massively parallel
RT signature sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:7940-7945(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- TISSUE SPECIFICITY: Testis specific. Expressed in cancer cell lines.
CC {ECO:0000269|PubMed:15905330}.
CC -!- SIMILARITY: Belongs to the CT45 family.
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DR EMBL; AY743710; AAW66465.1; -; mRNA.
DR EMBL; AC240441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590618; CAI41545.1; -; Genomic_DNA.
DR CCDS; CCDS76031.1; -.
DR RefSeq; NP_001278464.1; NM_001291535.1.
DR RefSeq; NP_001278469.1; NM_001291540.2.
DR RefSeq; NP_001308200.1; NM_001321271.1.
DR RefSeq; NP_689795.4; NM_152582.6.
DR RefSeq; XP_006724846.1; XM_006724783.2.
DR RefSeq; XP_006724859.1; XM_006724796.2.
DR RefSeq; XP_006724862.1; XM_006724799.2.
DR RefSeq; XP_011529543.1; XM_011531241.2.
DR RefSeq; XP_011529691.1; XM_011531389.2.
DR AlphaFoldDB; Q5DJT8; -.
DR SMR; Q5DJT8; -.
DR IntAct; Q5DJT8; 5.
DR STRING; 9606.ENSP00000474632; -.
DR GlyGen; Q5DJT8; 1 site.
DR iPTMnet; Q5DJT8; -.
DR PhosphoSitePlus; Q5DJT8; -.
DR BioMuta; CT45A2; -.
DR DMDM; 160017332; -.
DR EPD; Q5DJT8; -.
DR jPOST; Q5DJT8; -.
DR MassIVE; Q5DJT8; -.
DR PaxDb; Q5DJT8; -.
DR PRIDE; Q5DJT8; -.
DR Antibodypedia; 75887; 2 antibodies from 2 providers.
DR DNASU; 102723737; -.
DR Ensembl; ENST00000605791.7; ENSP00000474632.2; ENSG00000271449.8.
DR Ensembl; ENST00000612907.2; ENSP00000483619.1; ENSG00000271449.8.
DR GeneID; 102723680; -.
DR GeneID; 102723737; -.
DR GeneID; 728911; -.
DR KEGG; hsa:102723680; -.
DR KEGG; hsa:102723737; -.
DR KEGG; hsa:728911; -.
DR MANE-Select; ENST00000611660.5; ENSP00000481184.1; NM_001291535.1; NP_001278464.1.
DR MANE-Select; ENST00000612907.2; ENSP00000483619.1; NM_152582.7; NP_689795.4.
DR MANE-Select; ENST00000620704.5; ENSP00000483637.1; NM_001291540.2; NP_001278469.1.
DR CTD; 102723680; -.
DR CTD; 102723737; -.
DR CTD; 728911; -.
DR DisGeNET; 102723680; -.
DR DisGeNET; 102723737; -.
DR DisGeNET; 728911; -.
DR GeneCards; CT45A2; -.
DR HGNC; HGNC:28400; CT45A2.
DR HPA; ENSG00000271449; Not detected.
DR MIM; 300793; gene.
DR neXtProt; NX_Q5DJT8; -.
DR OpenTargets; ENSG00000271449; -.
DR PharmGKB; PA164718186; -.
DR VEuPathDB; HostDB:ENSG00000271449; -.
DR eggNOG; KOG3768; Eukaryota.
DR GeneTree; ENSGT00390000016655; -.
DR InParanoid; Q5DJT8; -.
DR OMA; KTGHGIP; -.
DR OrthoDB; 1187027at2759; -.
DR PhylomeDB; Q5DJT8; -.
DR PathwayCommons; Q5DJT8; -.
DR SignaLink; Q5DJT8; -.
DR BioGRID-ORCS; 102723680; 4 hits in 55 CRISPR screens.
DR BioGRID-ORCS; 102723737; 2 hits in 3 CRISPR screens.
DR BioGRID-ORCS; 728911; 11 hits in 174 CRISPR screens.
DR Pharos; Q5DJT8; Tdark.
DR PRO; PR:Q5DJT8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5DJT8; protein.
DR Bgee; ENSG00000271449; Expressed in prefrontal cortex and 13 other tissues.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR029307; INT_SG_DDX_CT_C.
DR Pfam; PF15300; INT_SG_DDX_CT_C; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..189
FT /note="Cancer/testis antigen family 45 member A2"
FT /id="PRO_0000308947"
FT CONFLICT 57
FT /note="K -> E (in Ref. 1; AAW66465)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="F -> S (in Ref. 1; AAW66465 and 2; CAI41545)"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="Q -> K (in Ref. 1; AAW66465 and 2; CAI41545)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 21363 MW; 2D1A638CBDCF3299 CRC64;
MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT
GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS SFSGDDLECR ETAFSPKSQQ
EINADIKRQL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH
LKKKLKRMI
