CT453_HUMAN
ID CT453_HUMAN Reviewed; 189 AA.
AC Q8NHU0; B2RU20; B7ZMC9; D3DTG6; P0DMU6; Q8N7B7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Cancer/testis antigen family 45 member A3 {ECO:0000312|HGNC:HGNC:33268};
DE AltName: Full=Cancer/testis antigen 45-3 {ECO:0000303|PubMed:15905330};
DE AltName: Full=Cancer/testis antigen 45-4 {ECO:0000303|PubMed:15905330};
DE AltName: Full=Cancer/testis antigen 45A3 {ECO:0000305};
DE AltName: Full=Cancer/testis antigen 45A4 {ECO:0000305};
DE AltName: Full=Cancer/testis antigen family 45 member A4 {ECO:0000312|HGNC:HGNC:33268};
GN Name=CT45A3 {ECO:0000312|HGNC:HGNC:33268};
GN Synonyms=CT45-3 {ECO:0000303|PubMed:15905330},
GN CT45-4 {ECO:0000303|PubMed:15905330}, CT45A4 {ECO:0000312|HGNC:HGNC:33268};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, IDENTIFICATION AS A
RP CANCER/TESTIS ANTIGEN, AND VARIANT ALA-55.
RX PubMed=15905330; DOI=10.1073/pnas.0502583102;
RA Chen Y.-T., Scanlan M.J., Venditti C.A., Chua R., Theiler G.,
RA Stevenson B.J., Iseli C., Gure A.O., Vasicek T., Strausberg R.L.,
RA Jongeneel C.V., Old L.J., Simpson A.J.G.;
RT "Identification of cancer/testis-antigen genes by massively parallel
RT signature sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:7940-7945(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-55.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-55.
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NHU0; Q92997: DVL3; NbExp=3; IntAct=EBI-8643558, EBI-739789;
CC Q8NHU0; O00560: SDCBP; NbExp=9; IntAct=EBI-8643558, EBI-727004;
CC Q8NHU0; Q9H190: SDCBP2; NbExp=8; IntAct=EBI-8643558, EBI-742426;
CC -!- TISSUE SPECIFICITY: Testis specific. Expressed in cancer cell lines.
CC {ECO:0000269|PubMed:15905330}.
CC -!- SIMILARITY: Belongs to the CT45 family.
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DR EMBL; AY743711; AAW66466.1; -; mRNA.
DR EMBL; AY743712; AAW66467.1; -; mRNA.
DR EMBL; AK098689; BAC05380.1; -; mRNA.
DR EMBL; AC240441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590618; CAI41546.1; -; Genomic_DNA.
DR EMBL; AL590618; CAI41549.1; -; Genomic_DNA.
DR EMBL; CH471107; EAX11718.1; -; Genomic_DNA.
DR EMBL; CH471107; EAX11719.1; -; Genomic_DNA.
DR EMBL; BC028711; AAH28711.1; -; mRNA.
DR EMBL; BC140735; AAI40736.1; -; mRNA.
DR EMBL; BC144437; AAI44438.1; -; mRNA.
DR EMBL; BC140926; AAI40927.1; -; mRNA.
DR CCDS; CCDS76030.1; -.
DR RefSeq; NP_001017435.1; NM_001017435.1.
DR RefSeq; XP_006724821.1; XM_006724758.3.
DR RefSeq; XP_011529642.1; XM_011531340.2.
DR AlphaFoldDB; Q8NHU0; -.
DR SMR; Q8NHU0; -.
DR BioGRID; 137546; 4.
DR IntAct; Q8NHU0; 7.
DR MINT; Q8NHU0; -.
DR STRING; 9606.ENSP00000471418; -.
DR GlyGen; Q8NHU0; 1 site.
DR iPTMnet; Q8NHU0; -.
DR PhosphoSitePlus; Q8NHU0; -.
DR BioMuta; CT45A3; -.
DR DMDM; 74751317; -.
DR jPOST; Q8NHU0; -.
DR MassIVE; Q8NHU0; -.
DR MaxQB; Q8NHU0; -.
DR PaxDb; Q8NHU0; -.
DR PeptideAtlas; Q8NHU0; -.
DR PRIDE; Q8NHU0; -.
DR Antibodypedia; 72422; 58 antibodies from 17 providers.
DR DNASU; 441519; -.
DR Ensembl; ENST00000597510.6; ENSP00000471418.1; ENSG00000269096.7.
DR Ensembl; ENST00000598716.3; ENSP00000471571.2; ENSG00000269096.7.
DR GeneID; 441519; -.
DR KEGG; hsa:441519; -.
DR MANE-Select; ENST00000598716.3; ENSP00000471571.2; NM_001370148.2; NP_001357077.1.
DR UCSC; uc065bga.1; human.
DR CTD; 441519; -.
DR GeneCards; CT45A3; -.
DR HGNC; HGNC:33268; CT45A3.
DR HPA; ENSG00000269096; Tissue enriched (testis).
DR MIM; 300794; gene.
DR MIM; 300795; gene.
DR neXtProt; NX_Q8NHU0; -.
DR PharmGKB; PA164718201; -.
DR VEuPathDB; HostDB:ENSG00000269096; -.
DR eggNOG; KOG3768; Eukaryota.
DR GeneTree; ENSGT00390000016655; -.
DR HOGENOM; CLU_123664_0_0_1; -.
DR InParanoid; Q8NHU0; -.
DR OMA; EAIVSTH; -.
DR OrthoDB; 1187027at2759; -.
DR PhylomeDB; Q8NHU0; -.
DR PathwayCommons; Q8NHU0; -.
DR SignaLink; Q8NHU0; -.
DR BioGRID-ORCS; 441519; 11 hits in 192 CRISPR screens.
DR GenomeRNAi; 441519; -.
DR Pharos; Q8NHU0; Tdark.
DR PRO; PR:Q8NHU0; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8NHU0; protein.
DR Bgee; ENSG00000269096; Expressed in right testis and 28 other tissues.
DR Genevisible; Q8NHU0; HS.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR029307; INT_SG_DDX_CT_C.
DR Pfam; PF15300; INT_SG_DDX_CT_C; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..189
FT /note="Cancer/testis antigen family 45 member A3"
FT /id="PRO_0000308948"
FT REGION 81..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 55
FT /note="E -> A (in dbSNP:rs200277856)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15772651, ECO:0000269|PubMed:15905330"
FT /id="VAR_075898"
FT CONFLICT 120
FT /note="R -> Q (in Ref. 1; AAW66467, 2; BAC05380 and 3;
FT CAI41549)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 21331 MW; 3A86AC9CB6D6F042 CRC64;
MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT
GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQR
EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH
LKKKLKRMI
