CT455_HUMAN
ID CT455_HUMAN Reviewed; 189 AA.
AC P0DMU8; A8K842; B7ZMC5; Q6NSH3;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2015, sequence version 1.
DT 03-AUG-2022, entry version 38.
DE RecName: Full=Cancer/testis antigen family 45 member A5 {ECO:0000312|HGNC:HGNC:33270};
DE AltName: Full=Cancer/testis antigen 45-5 {ECO:0000303|PubMed:15905330};
DE AltName: Full=Cancer/testis antigen 45A5 {ECO:0000305};
GN Name=CT45A5 {ECO:0000312|HGNC:HGNC:33270};
GN Synonyms=CT45-5 {ECO:0000303|PubMed:15905330};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND IDENTIFICATION AS A
RP CANCER/TESTIS ANTIGEN.
RX PubMed=15905330; DOI=10.1073/pnas.0502583102;
RA Chen Y.-T., Scanlan M.J., Venditti C.A., Chua R., Theiler G.,
RA Stevenson B.J., Iseli C., Gure A.O., Vasicek T., Strausberg R.L.,
RA Jongeneel C.V., Old L.J., Simpson A.J.G.;
RT "Identification of cancer/testis-antigen genes by massively parallel
RT signature sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:7940-7945(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- TISSUE SPECIFICITY: Testis specific. Expressed in cancer cell lines.
CC {ECO:0000269|PubMed:15905330}.
CC -!- SIMILARITY: Belongs to the CT45 family.
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DR EMBL; AY743713; AAW66468.1; -; mRNA.
DR EMBL; AC240441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590618; CAI41550.1; -; Genomic_DNA.
DR CCDS; CCDS35406.1; -.
DR RefSeq; NP_001007552.2; NM_001007551.4.
DR RefSeq; NP_001017438.2; NM_001017438.2.
DR RefSeq; NP_001165759.2; NM_001172288.2.
DR RefSeq; NP_001278456.1; NM_001291527.1.
DR RefSeq; NP_001278457.1; NM_001291528.1.
DR RefSeq; NP_001278458.1; NM_001291529.1.
DR RefSeq; NP_001278459.1; NM_001291530.1.
DR RefSeq; NP_001278472.1; NM_001291543.1.
DR RefSeq; XP_003960131.1; XM_003960082.4.
DR RefSeq; XP_005262482.2; XM_005262425.4.
DR RefSeq; XP_011529531.1; XM_011531229.2.
DR RefSeq; XP_011529540.1; XM_011531238.2.
DR RefSeq; XP_011529541.1; XM_011531239.1.
DR RefSeq; XP_011529643.1; XM_011531341.2.
DR RefSeq; XP_011529653.1; XM_011531351.1.
DR AlphaFoldDB; P0DMU8; -.
DR SMR; P0DMU8; -.
DR STRING; 9606.ENSP00000427342; -.
DR iPTMnet; P0DMU8; -.
DR PhosphoSitePlus; P0DMU8; -.
DR BioMuta; CT45A5; -.
DR jPOST; P0DMU8; -.
DR MassIVE; P0DMU8; -.
DR PRIDE; P0DMU8; -.
DR Antibodypedia; 56380; 5 antibodies from 4 providers.
DR DNASU; 441521; -.
DR Ensembl; ENST00000487941.6; ENSP00000427342.2; ENSG00000228836.8.
DR Ensembl; ENST00000617203.1; ENSP00000483658.1; ENSG00000228836.8.
DR GeneID; 101060211; -.
DR GeneID; 102723631; -.
DR GeneID; 441521; -.
DR GeneID; 541465; -.
DR KEGG; hsa:101060211; -.
DR KEGG; hsa:102723631; -.
DR KEGG; hsa:441521; -.
DR KEGG; hsa:541465; -.
DR MANE-Select; ENST00000610598.5; ENSP00000482241.1; NM_001394668.1; NP_001381597.1.
DR MANE-Select; ENST00000620654.2; ENSP00000479608.2; NM_001017438.3; NP_001017438.2.
DR CTD; 101060211; -.
DR CTD; 102723631; -.
DR CTD; 441521; -.
DR CTD; 541465; -.
DR GeneCards; CT45A5; -.
DR HGNC; HGNC:33270; CT45A5.
DR HPA; ENSG00000228836; Tissue enhanced (brain, pituitary gland, testis).
DR MIM; 300796; gene.
DR neXtProt; NX_P0DMU8; -.
DR OpenTargets; ENSG00000228836; -.
DR OpenTargets; ENSG00000278289; -.
DR VEuPathDB; HostDB:ENSG00000228836; -.
DR eggNOG; KOG3768; Eukaryota.
DR OMA; YPNCLAS; -.
DR OrthoDB; 1187027at2759; -.
DR PhylomeDB; P0DMU8; -.
DR PathwayCommons; P0DMU8; -.
DR BioGRID-ORCS; 101060211; 8 hits in 75 CRISPR screens.
DR BioGRID-ORCS; 102723631; 4 hits in 96 CRISPR screens.
DR BioGRID-ORCS; 441521; 6 hits in 611 CRISPR screens.
DR BioGRID-ORCS; 541465; 5 hits in 183 CRISPR screens.
DR Pharos; P0DMU8; Tdark.
DR PRO; PR:P0DMU8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P0DMU8; protein.
DR Bgee; ENSG00000228836; Expressed in right testis and 36 other tissues.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR029307; INT_SG_DDX_CT_C.
DR Pfam; PF15300; INT_SG_DDX_CT_C; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..189
FT /note="Cancer/testis antigen family 45 member A5"
FT /id="PRO_0000308950"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 101
FT /note="S -> N (in Ref. 1; AAW66468 and 2; CAI41550)"
FT /evidence="ECO:0000305"
FT CONFLICT 111..112
FT /note="ET -> GI (in Ref. 1; AAW66468 and 2; CAI41550)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="R -> Q (in Ref. 1; AAW66468 and 2; CAI41550)"
FT /evidence="ECO:0000305"
FT CONFLICT 128..139
FT /note="RKLVKELRCVGQ -> CQVVKEIRCLGR (in Ref. 1; AAW66468
FT and 2; CAI41550)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 21232 MW; 202C0D8DB6D6F042 CRC64;
MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT
GHAIPPSQLD SQIDDFTGFS KDGMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQR
EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH
LKKKLKRMI
