CT456_HUMAN
ID CT456_HUMAN Reviewed; 189 AA.
AC P0DMU7; Q8N7B7;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2015, sequence version 1.
DT 03-AUG-2022, entry version 39.
DE RecName: Full=Cancer/testis antigen family 45 member A6 {ECO:0000312|HGNC:HGNC:33271};
DE AltName: Full=Cancer/testis antigen 45-6 {ECO:0000303|PubMed:15905330};
DE AltName: Full=Cancer/testis antigen 45A6 {ECO:0000305};
GN Name=CT45A6 {ECO:0000312|HGNC:HGNC:33271};
GN Synonyms=CT45-6 {ECO:0000303|PubMed:15905330};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND IDENTIFICATION AS A
RP CANCER/TESTIS ANTIGEN.
RX PubMed=15905330; DOI=10.1073/pnas.0502583102;
RA Chen Y.-T., Scanlan M.J., Venditti C.A., Chua R., Theiler G.,
RA Stevenson B.J., Iseli C., Gure A.O., Vasicek T., Strausberg R.L.,
RA Jongeneel C.V., Old L.J., Simpson A.J.G.;
RT "Identification of cancer/testis-antigen genes by massively parallel
RT signature sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:7940-7945(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- TISSUE SPECIFICITY: Testis specific. Expressed in cancer cell lines.
CC {ECO:0000269|PubMed:15905330}.
CC -!- SIMILARITY: Belongs to the CT45 family.
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DR EMBL; AY743714; AAW66469.1; -; mRNA.
DR EMBL; AC240441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590618; CAI41551.1; -; Genomic_DNA.
DR CCDS; CCDS35407.1; -.
DR RefSeq; NP_001007552.2; NM_001007551.4.
DR RefSeq; NP_001017438.2; NM_001017438.2.
DR RefSeq; NP_001165759.2; NM_001172288.2.
DR RefSeq; NP_001278472.1; NM_001291543.1.
DR RefSeq; XP_003960131.1; XM_003960082.4.
DR RefSeq; XP_005262482.2; XM_005262425.4.
DR RefSeq; XP_011529531.1; XM_011531229.2.
DR RefSeq; XP_011529643.1; XM_011531341.2.
DR RefSeq; XP_011529653.1; XM_011531351.1.
DR AlphaFoldDB; P0DMU7; -.
DR SMR; P0DMU7; -.
DR iPTMnet; P0DMU7; -.
DR PhosphoSitePlus; P0DMU7; -.
DR BioMuta; CT45A6; -.
DR jPOST; P0DMU7; -.
DR MassIVE; P0DMU7; -.
DR PeptideAtlas; P0DMU7; -.
DR PRIDE; P0DMU7; -.
DR Antibodypedia; 77503; 1 antibodies from 1 providers.
DR DNASU; 441521; -.
DR Ensembl; ENST00000612878.4; ENSP00000483910.1; ENSG00000278289.5.
DR Ensembl; ENST00000620654.2; ENSP00000479608.2; ENSG00000278289.5.
DR GeneID; 101060211; -.
DR GeneID; 441521; -.
DR GeneID; 541465; -.
DR KEGG; hsa:101060211; -.
DR KEGG; hsa:441521; -.
DR KEGG; hsa:541465; -.
DR MANE-Select; ENST00000610598.5; ENSP00000482241.1; NM_001394668.1; NP_001381597.1.
DR MANE-Select; ENST00000620654.2; ENSP00000479608.2; NM_001017438.3; NP_001017438.2.
DR CTD; 101060211; -.
DR CTD; 441521; -.
DR CTD; 541465; -.
DR GeneCards; CT45A6; -.
DR HGNC; HGNC:33271; CT45A6.
DR HPA; ENSG00000278289; Tissue enhanced (pituitary gland, testis).
DR MIM; 300797; gene.
DR neXtProt; NX_P0DMU7; -.
DR OpenTargets; ENSG00000228836; -.
DR OpenTargets; ENSG00000278289; -.
DR VEuPathDB; HostDB:ENSG00000278289; -.
DR OMA; EIKCALM; -.
DR OrthoDB; 1187027at2759; -.
DR PhylomeDB; P0DMU7; -.
DR PathwayCommons; P0DMU7; -.
DR BioGRID-ORCS; 101060211; 8 hits in 75 CRISPR screens.
DR BioGRID-ORCS; 441521; 6 hits in 611 CRISPR screens.
DR BioGRID-ORCS; 541465; 5 hits in 183 CRISPR screens.
DR Pharos; P0DMU7; Tdark.
DR PRO; PR:P0DMU7; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P0DMU7; protein.
DR Bgee; ENSG00000278289; Expressed in right testis and 24 other tissues.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR029307; INT_SG_DDX_CT_C.
DR Pfam; PF15300; INT_SG_DDX_CT_C; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..189
FT /note="Cancer/testis antigen family 45 member A6"
FT /id="PRO_0000433117"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 55
FT /note="E -> A (in Ref. 3; CAI41551 and 1; AAW66469)"
FT /evidence="ECO:0000305"
FT CONFLICT 83
FT /note="G -> R (in Ref. 3; CAI41551 and 1; AAW66469)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="R -> Q (in Ref. 3; CAI41551 and 1; AAW66469)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 21232 MW; 202C0D8DB6D6F042 CRC64;
MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT
GHAIPPSQLD SQIDDFTGFS KDGMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQR
EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH
LKKKLKRMI
