ID   CT458_HUMAN             Reviewed;         189 AA.
AC   P0DMV1;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2015, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Cancer/testis antigen family 45 member A8 {ECO:0000312|HGNC:HGNC:51261};
DE   AltName: Full=Cancer/testis antigen 45A8 {ECO:0000305};
GN   Name=CT45A8 {ECO:0000312|HGNC:HGNC:51261};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
CC   -!- SIMILARITY: Belongs to the CT45 family.
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DR   EMBL; AC240441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS76033.1; -.
DR   RefSeq; NP_001278464.1; NM_001291535.1.
DR   RefSeq; NP_001278469.1; NM_001291540.2.
DR   RefSeq; NP_001308200.1; NM_001321271.1.
DR   RefSeq; NP_689795.4; NM_152582.6.
DR   RefSeq; XP_006724846.1; XM_006724783.2.
DR   RefSeq; XP_006724859.1; XM_006724796.2.
DR   RefSeq; XP_006724862.1; XM_006724799.2.
DR   RefSeq; XP_011529543.1; XM_011531241.2.
DR   RefSeq; XP_011529691.1; XM_011531389.2.
DR   AlphaFoldDB; P0DMV1; -.
DR   SMR; P0DMV1; -.
DR   iPTMnet; P0DMV1; -.
DR   PhosphoSitePlus; P0DMV1; -.
DR   BioMuta; CT45A8; -.
DR   jPOST; P0DMV1; -.
DR   MassIVE; P0DMV1; -.
DR   PeptideAtlas; P0DMV1; -.
DR   PRIDE; P0DMV1; -.
DR   Antibodypedia; 75731; 37 antibodies from 6 providers.
DR   DNASU; 102723737; -.
DR   Ensembl; ENST00000611438.1; ENSP00000480644.1; ENSG00000278085.5.
DR   Ensembl; ENST00000611660.5; ENSP00000481184.1; ENSG00000278085.5.
DR   GeneID; 102723680; -.
DR   GeneID; 102723737; -.
DR   GeneID; 728911; -.
DR   KEGG; hsa:102723680; -.
DR   KEGG; hsa:102723737; -.
DR   KEGG; hsa:728911; -.
DR   MANE-Select; ENST00000611660.5; ENSP00000481184.1; NM_001291535.1; NP_001278464.1.
DR   MANE-Select; ENST00000612907.2; ENSP00000483619.1; NM_152582.7; NP_689795.4.
DR   MANE-Select; ENST00000620704.5; ENSP00000483637.1; NM_001291540.2; NP_001278469.1.
DR   CTD; 102723680; -.
DR   CTD; 102723737; -.
DR   CTD; 728911; -.
DR   DisGeNET; 102723680; -.
DR   DisGeNET; 102723737; -.
DR   DisGeNET; 728911; -.
DR   GeneCards; CT45A8; -.
DR   HGNC; HGNC:51261; CT45A8.
DR   HPA; ENSG00000278085; Not detected.
DR   neXtProt; NX_P0DMV1; -.
DR   OpenTargets; ENSG00000271449; -.
DR   VEuPathDB; HostDB:ENSG00000278085; -.
DR   OMA; ARYMSGD; -.
DR   OrthoDB; 1187027at2759; -.
DR   PhylomeDB; P0DMV1; -.
DR   PathwayCommons; P0DMV1; -.
DR   BioGRID-ORCS; 102723680; 4 hits in 55 CRISPR screens.
DR   BioGRID-ORCS; 102723737; 2 hits in 3 CRISPR screens.
DR   BioGRID-ORCS; 728911; 11 hits in 174 CRISPR screens.
DR   Pharos; P0DMV1; Tdark.
DR   PRO; PR:P0DMV1; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; P0DMV1; protein.
DR   Bgee; ENSG00000278085; Expressed in prefrontal cortex and 17 other tissues.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   InterPro; IPR029307; INT_SG_DDX_CT_C.
DR   Pfam; PF15300; INT_SG_DDX_CT_C; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..189
FT                   /note="Cancer/testis antigen family 45 member A8"
FT                   /id="PRO_0000433030"
SQ   SEQUENCE   189 AA;  21363 MW;  2D1A638CBDCF3299 CRC64;
     MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT
     GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS SFSGDDLECR ETAFSPKSQQ
     EINADIKRQL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH
     LKKKLKRMI