CT47A_HUMAN
ID CT47A_HUMAN Reviewed; 288 AA.
AC Q5JQC4; Q8N747;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Cancer/testis antigen 47A;
DE AltName: Full=Cancer/testis antigen 47;
DE Short=CT47;
GN Name=CT47A1; Synonyms=CT47.1;
GN and
GN Name=CT47A2; Synonyms=CT47.2;
GN and
GN Name=CT47A3; Synonyms=CT47.3;
GN and
GN Name=CT47A4; Synonyms=CT47.4;
GN and
GN Name=CT47A5; Synonyms=CT47.5;
GN and
GN Name=CT47A6; Synonyms=CT47.6;
GN and
GN Name=CT47A7; Synonyms=CT47.7;
GN and
GN Name=CT47A8; Synonyms=CT47.8;
GN and
GN Name=CT47A9; Synonyms=CT47.9;
GN and
GN Name=CT47A10; Synonyms=CT47.10;
GN and
GN Name=CT47A11; Synonyms=CT47.11;
GN and
GN Name=CT47A12; Synonyms=CT47.12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=16382448; DOI=10.1002/gcc.20298;
RA Chen Y.-T., Iseli C., Venditti C.A., Old L.J., Simpson A.J.G.,
RA Jongeneel C.V.;
RT "Identification of a new cancer/testis gene family, CT47, among expressed
RT multicopy genes on the human X chromosome.";
RL Genes Chromosomes Cancer 45:392-400(2006).
CC -!- TISSUE SPECIFICITY: Strongly expressed in testis, low expression in
CC placenta, and very low expression in brain.
CC {ECO:0000269|PubMed:16382448}.
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DR EMBL; AL670379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC008162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029540; AAH29540.1; -; mRNA.
DR CCDS; CCDS35381.1; -.
DR CCDS; CCDS35382.1; -.
DR CCDS; CCDS35383.1; -.
DR CCDS; CCDS35384.1; -.
DR CCDS; CCDS35385.1; -.
DR CCDS; CCDS35386.1; -.
DR CCDS; CCDS35387.1; -.
DR CCDS; CCDS35388.1; -.
DR CCDS; CCDS35389.1; -.
DR CCDS; CCDS35390.1; -.
DR CCDS; CCDS35391.1; -.
DR CCDS; CCDS56607.1; -.
DR RefSeq; NP_001073606.1; NM_001080137.1.
DR RefSeq; NP_001073607.1; NM_001080138.1.
DR RefSeq; NP_001073608.1; NM_001080139.1.
DR RefSeq; NP_001073609.1; NM_001080140.1.
DR RefSeq; NP_001073610.1; NM_001080141.1.
DR RefSeq; NP_001073611.1; NM_001080142.1.
DR RefSeq; NP_001073612.1; NM_001080143.1.
DR RefSeq; NP_001073613.1; NM_001080144.1.
DR RefSeq; NP_001073614.1; NM_001080145.1.
DR RefSeq; NP_001073615.1; NM_001080146.1.
DR RefSeq; NP_001229851.1; NM_001242922.1.
DR RefSeq; NP_775842.2; NM_173571.2.
DR AlphaFoldDB; Q5JQC4; -.
DR BioGRID; 129092; 1.
DR BioGRID; 1528822; 1.
DR BioGRID; 575663; 1.
DR BioGRID; 608472; 1.
DR BioGRID; 608478; 1.
DR BioGRID; 608485; 1.
DR BioGRID; 608498; 1.
DR BioGRID; 608508; 1.
DR BioGRID; 608511; 1.
DR BioGRID; 608518; 1.
DR BioGRID; 608526; 1.
DR BioGRID; 608532; 1.
DR IntAct; Q5JQC4; 1.
DR MINT; Q5JQC4; -.
DR STRING; 9606.ENSP00000389513; -.
DR iPTMnet; Q5JQC4; -.
DR PhosphoSitePlus; Q5JQC4; -.
DR BioMuta; CT47A11; -.
DR DMDM; 74741726; -.
DR MassIVE; Q5JQC4; -.
DR MaxQB; Q5JQC4; -.
DR PaxDb; Q5JQC4; -.
DR PeptideAtlas; Q5JQC4; -.
DR PRIDE; Q5JQC4; -.
DR ProteomicsDB; 63038; -.
DR Antibodypedia; 70797; 25 antibodies from 10 providers.
DR Antibodypedia; 72694; 14 antibodies from 4 providers.
DR Antibodypedia; 76817; 1 antibodies from 1 providers.
DR Antibodypedia; 76845; 3 antibodies from 3 providers.
DR Antibodypedia; 77501; 5 antibodies from 2 providers.
DR Antibodypedia; 77773; 1 antibodies from 1 providers.
DR DNASU; 255313; -.
DR Ensembl; ENST00000415858.3; ENSP00000389513.2; ENSG00000230594.3.
DR Ensembl; ENST00000417256.3; ENSP00000408204.2; ENSG00000226600.3.
DR Ensembl; ENST00000419194.3; ENSP00000399711.2; ENSG00000226023.6.
DR Ensembl; ENST00000419982.3; ENSP00000391318.2; ENSG00000226685.4.
DR Ensembl; ENST00000430448.3; ENSP00000411909.2; ENSG00000224089.3.
DR Ensembl; ENST00000433030.4; ENSP00000393315.1; ENSG00000236371.6.
DR Ensembl; ENST00000434883.3; ENSP00000392283.2; ENSG00000228517.3.
DR Ensembl; ENST00000439466.3; ENSP00000390070.2; ENSG00000237957.6.
DR Ensembl; ENST00000441330.3; ENSP00000398559.2; ENSG00000236126.3.
DR Ensembl; ENST00000457020.3; ENSP00000410400.2; ENSG00000226929.3.
DR Ensembl; ENST00000457977.3; ENSP00000400046.2; ENSG00000230347.5.
DR Ensembl; ENST00000458218.3; ENSP00000414253.2; ENSG00000242362.2.
DR Ensembl; ENST00000672229.1; ENSP00000500004.1; ENSG00000288363.1.
DR Ensembl; ENST00000672380.1; ENSP00000500110.1; ENSG00000288477.1.
DR Ensembl; ENST00000673456.1; ENSP00000500057.1; ENSG00000288273.1.
DR GeneID; 100507170; -.
DR GeneID; 255313; -.
DR GeneID; 653282; -.
DR GeneID; 728036; -.
DR GeneID; 728042; -.
DR GeneID; 728049; -.
DR GeneID; 728062; -.
DR GeneID; 728072; -.
DR GeneID; 728075; -.
DR GeneID; 728082; -.
DR GeneID; 728090; -.
DR GeneID; 728096; -.
DR KEGG; hsa:100507170; -.
DR KEGG; hsa:255313; -.
DR KEGG; hsa:653282; -.
DR KEGG; hsa:728036; -.
DR KEGG; hsa:728042; -.
DR KEGG; hsa:728049; -.
DR KEGG; hsa:728062; -.
DR KEGG; hsa:728072; -.
DR KEGG; hsa:728075; -.
DR KEGG; hsa:728082; -.
DR KEGG; hsa:728090; -.
DR KEGG; hsa:728096; -.
DR MANE-Select; ENST00000415858.3; ENSP00000389513.2; NM_001080143.2; NP_001073612.1.
DR MANE-Select; ENST00000417256.3; ENSP00000408204.2; NM_001080138.2; NP_001073607.1.
DR MANE-Select; ENST00000419194.3; ENSP00000399711.2; NM_001080141.2; NP_001073610.1.
DR MANE-Select; ENST00000430448.3; ENSP00000411909.2; NM_001080137.2; NP_001073606.1.
DR MANE-Select; ENST00000433030.4; ENSP00000393315.1; NM_001080146.3; NP_001073615.1.
DR MANE-Select; ENST00000434883.3; ENSP00000392283.2; NM_001080140.1; NP_001073609.1.
DR MANE-Select; ENST00000439466.3; ENSP00000390070.2; NM_001080142.2; NP_001073611.1.
DR MANE-Select; ENST00000441330.3; ENSP00000398559.2; NM_001080144.2; NP_001073613.1.
DR MANE-Select; ENST00000457020.3; ENSP00000410400.2; NM_173571.2; NP_775842.2.
DR MANE-Select; ENST00000457977.3; ENSP00000400046.2; NM_001080139.2; NP_001073608.1.
DR MANE-Select; ENST00000458218.3; ENSP00000414253.2; NM_001080145.2; NP_001073614.1.
DR UCSC; uc004eta.4; human.
DR CTD; 100507170; -.
DR CTD; 255313; -.
DR CTD; 653282; -.
DR CTD; 728036; -.
DR CTD; 728042; -.
DR CTD; 728049; -.
DR CTD; 728062; -.
DR CTD; 728072; -.
DR CTD; 728075; -.
DR CTD; 728082; -.
DR CTD; 728090; -.
DR CTD; 728096; -.
DR DisGeNET; 100507170; -.
DR DisGeNET; 255313; -.
DR DisGeNET; 653282; -.
DR DisGeNET; 728036; -.
DR DisGeNET; 728042; -.
DR DisGeNET; 728049; -.
DR DisGeNET; 728062; -.
DR DisGeNET; 728072; -.
DR DisGeNET; 728075; -.
DR DisGeNET; 728082; -.
DR DisGeNET; 728090; -.
DR DisGeNET; 728096; -.
DR GeneCards; CT47A1; -.
DR GeneCards; CT47A10; -.
DR GeneCards; CT47A11; -.
DR GeneCards; CT47A12; -.
DR GeneCards; CT47A2; -.
DR GeneCards; CT47A3; -.
DR GeneCards; CT47A4; -.
DR GeneCards; CT47A5; -.
DR GeneCards; CT47A6; -.
DR GeneCards; CT47A7; -.
DR GeneCards; CT47A8; -.
DR GeneCards; CT47A9; -.
DR HGNC; HGNC:33282; CT47A1.
DR HGNC; HGNC:33291; CT47A10.
DR HGNC; HGNC:27397; CT47A11.
DR HGNC; HGNC:33292; CT47A12.
DR HGNC; HGNC:33283; CT47A2.
DR HGNC; HGNC:33284; CT47A3.
DR HGNC; HGNC:33285; CT47A4.
DR HGNC; HGNC:33286; CT47A5.
DR HGNC; HGNC:33287; CT47A6.
DR HGNC; HGNC:33288; CT47A7.
DR HGNC; HGNC:33289; CT47A8.
DR HGNC; HGNC:33290; CT47A9.
DR HPA; ENSG00000224089; Not detected.
DR HPA; ENSG00000226023; Not detected.
DR HPA; ENSG00000226600; Not detected.
DR HPA; ENSG00000226685; Tissue enriched (testis).
DR HPA; ENSG00000226929; Tissue enriched (testis).
DR HPA; ENSG00000228517; Not detected.
DR HPA; ENSG00000230347; Not detected.
DR HPA; ENSG00000230594; Not detected.
DR HPA; ENSG00000236126; Not detected.
DR HPA; ENSG00000236371; Not detected.
DR HPA; ENSG00000237957; Not detected.
DR HPA; ENSG00000242362; Not detected.
DR MIM; 300592; gene.
DR MIM; 300780; gene.
DR MIM; 300781; gene.
DR MIM; 300782; gene.
DR MIM; 300783; gene.
DR MIM; 300784; gene.
DR MIM; 300785; gene.
DR MIM; 300786; gene.
DR MIM; 300787; gene.
DR MIM; 300788; gene.
DR MIM; 300789; gene.
DR neXtProt; NX_Q5JQC4; -.
DR OpenTargets; ENSG00000236371; -.
DR PharmGKB; PA164718206; -.
DR VEuPathDB; HostDB:ENSG00000224089; -.
DR VEuPathDB; HostDB:ENSG00000226023; -.
DR VEuPathDB; HostDB:ENSG00000226600; -.
DR VEuPathDB; HostDB:ENSG00000226685; -.
DR VEuPathDB; HostDB:ENSG00000226929; -.
DR VEuPathDB; HostDB:ENSG00000228517; -.
DR VEuPathDB; HostDB:ENSG00000230347; -.
DR VEuPathDB; HostDB:ENSG00000230594; -.
DR VEuPathDB; HostDB:ENSG00000236126; -.
DR VEuPathDB; HostDB:ENSG00000236371; -.
DR VEuPathDB; HostDB:ENSG00000237957; -.
DR VEuPathDB; HostDB:ENSG00000242362; -.
DR eggNOG; ENOG502TF73; Eukaryota.
DR GeneTree; ENSGT00390000002253; -.
DR HOGENOM; CLU_083200_0_0_1; -.
DR InParanoid; Q5JQC4; -.
DR OMA; HRINCNN; -.
DR OrthoDB; 1629068at2759; -.
DR PhylomeDB; Q5JQC4; -.
DR TreeFam; TF342556; -.
DR PathwayCommons; Q5JQC4; -.
DR SignaLink; Q5JQC4; -.
DR BioGRID-ORCS; 100507170; 3 hits in 90 CRISPR screens.
DR BioGRID-ORCS; 255313; 2 hits in 96 CRISPR screens.
DR BioGRID-ORCS; 653282; 5 hits in 114 CRISPR screens.
DR BioGRID-ORCS; 728036; 1 hit in 101 CRISPR screens.
DR BioGRID-ORCS; 728042; 3 hits in 89 CRISPR screens.
DR BioGRID-ORCS; 728049; 4 hits in 112 CRISPR screens.
DR BioGRID-ORCS; 728062; 4 hits in 112 CRISPR screens.
DR BioGRID-ORCS; 728072; 3 hits in 97 CRISPR screens.
DR BioGRID-ORCS; 728075; 1 hit in 83 CRISPR screens.
DR BioGRID-ORCS; 728082; 2 hits in 94 CRISPR screens.
DR BioGRID-ORCS; 728090; 2 hits in 92 CRISPR screens.
DR BioGRID-ORCS; 728096; 8 hits in 132 CRISPR screens.
DR Pharos; Q5JQC4; Tdark.
DR PRO; PR:Q5JQC4; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5JQC4; protein.
DR Bgee; ENSG00000224089; Expressed in right testis and 1 other tissue.
DR Genevisible; Q5JQC4; HS.
DR InterPro; IPR028930; CT47.
DR PANTHER; PTHR32157; PTHR32157; 1.
DR Pfam; PF15623; CT47; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..288
FT /note="Cancer/testis antigen 47A"
FT /id="PRO_0000284450"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 259..287
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..102
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..236
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 161
FT /note="L -> P (in Ref. 2; AAH29540)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 288 AA; 30100 MW; AED9537B9C8EBF60 CRC64;
MSATGDRHPT QGDQEAPVSQ EGAQAEAAGA GNQEGGDSGP DSSDVVPAAE VVGVAGPVEG
LGEEEGEQAA GLAAVPRGGS AEEDSDIGPA TEEEEEEEGN EAANFDLAVV ARRYPASGIH
FVLLDMVHSL LHRLSHNDHI LIENRQLSRL MVGPHAAARN LWGNLPPLLL PQRLGAGAAA
RAGEGLGLIQ EAASVPEPAV PADLAEMARE PAEEAAEEKL SEEATEEPDA EEPATEEPTA
QEATAPEEVT KSQPEKWDEE AQDAAGEEEK EQEKEKDAEN KVKNSKGT
