CT47B_HUMAN
ID CT47B_HUMAN Reviewed; 299 AA.
AC P0C2W7; A6NM97;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Cancer/testis antigen 47B;
DE AltName: Full=Cancer/testis antigen 47.13;
DE Short=CT47.13;
GN Name=CT47B1; Synonyms=CT47.13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=16382448; DOI=10.1002/gcc.20298;
RA Chen Y.-T., Iseli C., Venditti C.A., Old L.J., Simpson A.J.G.,
RA Jongeneel C.V.;
RT "Identification of a new cancer/testis gene family, CT47, among expressed
RT multicopy genes on the human X chromosome.";
RL Genes Chromosomes Cancer 45:392-400(2006).
RN [3]
RP VARIANT GLU-99 DEL.
RX PubMed=23092983; DOI=10.1038/tp.2012.102;
RA Nava C., Lamari F., Heron D., Mignot C., Rastetter A., Keren B., Cohen D.,
RA Faudet A., Bouteiller D., Gilleron M., Jacquette A., Whalen S., Afenjar A.,
RA Perisse D., Laurent C., Dupuits C., Gautier C., Gerard M., Huguet G.,
RA Caillet S., Leheup B., Leboyer M., Gillberg C., Delorme R., Bourgeron T.,
RA Brice A., Depienne C.;
RT "Analysis of the chromosome X exome in patients with autism spectrum
RT disorders identified novel candidate genes, including TMLHE.";
RL Transl. Psychiatry 2:E179-E179(2012).
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DR EMBL; AC008162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48161.1; -.
DR RefSeq; NP_001139190.1; NM_001145718.1.
DR AlphaFoldDB; P0C2W7; -.
DR STRING; 9606.ENSP00000360360; -.
DR BioMuta; CT47B1; -.
DR DMDM; 146286097; -.
DR MassIVE; P0C2W7; -.
DR PaxDb; P0C2W7; -.
DR PeptideAtlas; P0C2W7; -.
DR PRIDE; P0C2W7; -.
DR ProteomicsDB; 52306; -.
DR Antibodypedia; 70794; 17 antibodies from 8 providers.
DR DNASU; 643311; -.
DR Ensembl; ENST00000371311.5; ENSP00000360360.3; ENSG00000236446.4.
DR Ensembl; ENST00000672355.1; ENSP00000500741.1; ENSG00000288466.1.
DR GeneID; 643311; -.
DR KEGG; hsa:643311; -.
DR MANE-Select; ENST00000371311.5; ENSP00000360360.3; NM_001145718.3; NP_001139190.1.
DR UCSC; uc011muc.3; human.
DR CTD; 643311; -.
DR GeneCards; CT47B1; -.
DR HGNC; HGNC:33293; CT47B1.
DR HPA; ENSG00000236446; Tissue enriched (testis).
DR MIM; 300790; gene.
DR neXtProt; NX_P0C2W7; -.
DR OpenTargets; ENSG00000236446; -.
DR PharmGKB; PA164718327; -.
DR VEuPathDB; HostDB:ENSG00000236446; -.
DR eggNOG; ENOG502TF73; Eukaryota.
DR GeneTree; ENSGT00390000002253; -.
DR HOGENOM; CLU_083200_0_0_1; -.
DR InParanoid; P0C2W7; -.
DR OMA; NLWDNPP; -.
DR OrthoDB; 1561192at2759; -.
DR PhylomeDB; P0C2W7; -.
DR TreeFam; TF342556; -.
DR PathwayCommons; P0C2W7; -.
DR BioGRID-ORCS; 643311; 8 hits in 668 CRISPR screens.
DR GenomeRNAi; 643311; -.
DR Pharos; P0C2W7; Tdark.
DR PRO; PR:P0C2W7; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P0C2W7; protein.
DR Bgee; ENSG00000236446; Expressed in right testis and 2 other tissues.
DR Genevisible; P0C2W7; HS.
DR InterPro; IPR028930; CT47.
DR PANTHER; PTHR32157; PTHR32157; 1.
DR Pfam; PF15623; CT47; 1.
PE 4: Predicted;
KW Coiled coil; Reference proteome.
FT CHAIN 1..299
FT /note="Cancer/testis antigen 47B"
FT /id="PRO_0000286433"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 270..298
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..102
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..254
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 99
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:23092983"
FT /id="VAR_076267"
SQ SEQUENCE 299 AA; 31319 MW; E2FD8473EE062757 CRC64;
MSATGDRHPT QGDQEAPVSQ EGAQAEAAGA GNQEGGDSGP DSSDMVPAAE VVGVAGPVEG
LGEEEGEQAA GLAAVPQGGS AEEDSDIGPA TEEEEEEEEG NEAANFDLAV ATRRYPAAGI
GFVFLYLVHS LLRRLYHNDH IQIANRHLSR LMVGPHAAVP NLWDNPPLLL LSQRLGAGAA
APEGEGLGLI QEAASVQEAA SVPEPAVPAD LAEMAREPAE EAADEKPPEE AAEEKLTEEA
TEEPAAEEPT SEEAVAPEEV TKSQPEKWDE EAQDAAGEEE KEQEKEKDVE NKVKNSKGT
