CT51A_CONTE
ID CT51A_CONTE Reviewed; 62 AA.
AC Q3YEE9;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Conotoxin TeAr151 {ECO:0000303|PubMed:16765485};
DE Contains:
DE RecName: Full=Conotoxin TeAr151 b {ECO:0000305};
DE Flags: Precursor;
OS Conus textile (Cloth-of-gold cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX NCBI_TaxID=6494;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=16765485; DOI=10.1016/j.peptides.2006.05.002;
RA Luo S., Zhangsun D., Zhang B., Chen X., Feng J.;
RT "Direct cDNA cloning of novel conotoxins of the T-superfamily from Conus
RT textile.";
RL Peptides 27:2640-2646(2006).
RN [2]
RP PROTEIN SEQUENCE OF 50-60, SUBCELLULAR LOCATION, MASS SPECTROMETRY,
RP OXIDATION AT MET-55, AND AMIDATION AT SER-60.
RC TISSUE=Venom;
RX PubMed=19380747; DOI=10.1073/pnas.0900745106;
RA Ueberheide B.M., Fenyo D., Alewood P.F., Chait B.T.;
RT "Rapid sensitive analysis of cysteine rich peptide venom components.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:6910-6915(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND AMIDATION AT
RP SER-60.
RC TISSUE=Venom;
RX PubMed=22709442; DOI=10.1021/pr300312h;
RA Bhatia S., Kil Y.J., Ueberheide B., Chait B.T., Tayo L., Cruz L., Lu B.,
RA Yates J.R. III, Bern M.;
RT "Constrained de novo sequencing of conotoxins.";
RL J. Proteome Res. 11:4191-4200(2012).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, POSITION IN VENOM
RP DUCT, AND AMIDATION AT SER-60.
RC TISSUE=Venom;
RX PubMed=23031820; DOI=10.1016/j.toxicon.2012.09.013;
RA Dobson R., Collodoro M., Gilles N., Turtoi A., De Pauw E., Quinton L.;
RT "Secretion and maturation of conotoxins in the venom ducts of Conus
RT textile.";
RL Toxicon 60:1370-1379(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19380747}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct (PubMed:19380747,
CC PubMed:23031820). Is mostly present in part 5 of the venom duct (distal
CC part near the pharynx), and less abundantly present in part 4 of the
CC venom duct (PubMed:23031820). {ECO:0000305|PubMed:19380747,
CC ECO:0000305|PubMed:23031820}.
CC -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC -!- PTM: Contains 2 disulfide bonds. {ECO:0000269|PubMed:19380747}.
CC -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC 'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC and AC P81755)... {ECO:0000305}.
CC -!- MASS SPECTROMETRY: [Conotoxin TeAr151]: Mass=1238.416; Mass_error=0.05;
CC Method=Electrospray; Note=Without oxidation at Met-55.;
CC Evidence={ECO:0000269|PubMed:19380747};
CC -!- MASS SPECTROMETRY: [Conotoxin TeAr151]: Mass=1254.405; Mass_error=0.05;
CC Method=Electrospray; Note=With oxidation at Met-55.;
CC Evidence={ECO:0000269|PubMed:19380747};
CC -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR EMBL; DQ141164; AAZ85411.1; -; mRNA.
DR AlphaFoldDB; Q3YEE9; -.
DR ConoServer; 1682; TeAr151 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR031565; T-conotoxin.
DR Pfam; PF16981; Chi-conotoxin; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Oxidation; Secreted; Signal; Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..47
FT /evidence="ECO:0000305|PubMed:19380747"
FT /id="PRO_0000274094"
FT PEPTIDE 50..60
FT /note="Conotoxin TeAr151"
FT /evidence="ECO:0000269|PubMed:19380747"
FT /id="PRO_0000274095"
FT PEPTIDE 51..60
FT /note="Conotoxin TeAr151 b"
FT /evidence="ECO:0000305|PubMed:22709442"
FT /id="PRO_0000445114"
FT MOD_RES 55
FT /note="Methionine sulfoxide; partial"
FT /evidence="ECO:0000269|PubMed:19380747"
FT MOD_RES 60
FT /note="Serine amide"
FT /evidence="ECO:0000269|PubMed:19380747,
FT ECO:0000269|PubMed:22709442, ECO:0000269|PubMed:23031820"
SQ SEQUENCE 62 AA; 6834 MW; 37930ADB8105E1ED CRC64;
MRCLPVFVVL LLLIASAPSV DAQPKTKDDV PLAPLHDNIQ NTLQTLRKKV CCRPMQDCCS
GK
