ID   CT51_CONVE              Reviewed;          60 AA.
AC   Q9BPG5; Q9BPG4;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Conotoxin VnMRCL-012 {ECO:0000303|PubMed:11158371};
DE   AltName: Full=VnMRCL-03 {ECO:0000303|PubMed:11158371};
DE   Flags: Precursor;
OS   Conus ventricosus (Mediterranean cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lautoconus.
OX   NCBI_TaxID=117992;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS VNMRCL-012 AND VNMRCL-03).
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:11158371}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=VnMRCL-012;
CC         IsoId=Q9BPG5-1; Sequence=Displayed;
CC       Name=VnMRCL-03;
CC         IsoId=Q9BPG5-2; Sequence=VSP_038850;
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:11158371}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; AF214964; AAG60392.1; -; mRNA.
DR   EMBL; AF214965; AAG60393.1; -; mRNA.
DR   AlphaFoldDB; Q9BPG5; -.
DR   ConoServer; 651; Vn5.1 precursor.
DR   ConoServer; 652; Vn5.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cleavage on pair of basic residues; Disulfide bond;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..50
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392723"
FT   PEPTIDE         51..60
FT                   /note="Conotoxin VnMRCL-012"
FT                   /id="PRO_0000392724"
FT   VAR_SEQ         22..36
FT                   /note="Missing (in isoform VnMRCL-03)"
FT                   /evidence="ECO:0000303|PubMed:11158371"
FT                   /id="VSP_038850"
SQ   SEQUENCE   60 AA;  6802 MW;  17D28AB5BE67A88B CRC64;
     MRCLPVFVIL LLLIASAPGV DAQPKTKYDV PLASRHDFAK KTPKRLSKPR DCCRRNFLCC