ID   CT52_CONGL              Reviewed;          62 AA.
AC   Q9U6Z8;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Conotoxin Gm5.2 {ECO:0000303|PubMed:10521453};
DE   Flags: Precursor;
OS   Conus gloriamaris (Glory-of-the-Sea cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=37336;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=10521453; DOI=10.1074/jbc.274.43.30664;
RA   Walker C.S., Steel D., Jacobsen R.B., Lirazan M.B., Cruz L.J., Hooper D.,
RA   Shetty R., DelaCruz R.C., Nielsen J.S., Zhou L.M., Bandyopadhyay P.,
RA   Craig A.G., Olivera B.M.;
RT   "The T-superfamily of conotoxins.";
RL   J. Biol. Chem. 274:30664-30671(1999).
RN   [2]
RP   ERRATUM OF PUBMED:10521453.
RA   Walker C.S., Steel D., Jacobsen R.B., Lirazan M.B., Cruz L.J., Hooper D.,
RA   Shetty R., DelaCruz R.C., Nielsen J.S., Zhou L.M., Bandyopadhyay P.,
RA   Craig A.G., Olivera B.M.;
RL   J. Biol. Chem. 274:36030-36030(1999).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:10521453}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:10521453}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; AF167166; AAF03686.1; -; mRNA.
DR   PIR; D59147; D59147.
DR   AlphaFoldDB; Q9U6Z8; -.
DR   ConoServer; 1732; Gm5.2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..49
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000035023"
FT   PEPTIDE         50..60
FT                   /note="Conotoxin Gm5.2"
FT                   /id="PRO_0000035024"
FT   MOD_RES         60
FT                   /note="Serine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   62 AA;  6817 MW;  6C8C0ADB810732C9 CRC64;
     MRCLPVFVIL LLLIASAPSV DAQPKTKDDV PLAPLHDNIR STLQTLRKKV CCRPVQDCCS
     GK