ID   CT52_CONLE              Reviewed;          68 AA.
AC   Q6PN80;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Conotoxin Lp5.2 {ECO:0000303|PubMed:16604269};
DE   Flags: Precursor;
OS   Conus leopardus (Leopard cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lithoconus.
OX   NCBI_TaxID=101306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16604269; DOI=10.1111/j.1745-7270.2006.00159.x;
RA   Chen W.-H., Han Y.-H., Wang Q., Miao X.-W., Ou L., Shao X.-X.;
RT   "cDNA cloning of two novel T-superfamily conotoxins from Conus leopardus.";
RL   Acta Biochim. Biophys. Sin. 38:287-291(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:16604269}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:16604269}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; AY591770; AAT01634.1; -; mRNA.
DR   AlphaFoldDB; Q6PN80; -.
DR   ConoServer; 861; Lp5.2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..54
FT                   /evidence="ECO:0000305|PubMed:16604269"
FT                   /id="PRO_0000234821"
FT   PEPTIDE         55..68
FT                   /note="Conotoxin Lp5.2"
FT                   /evidence="ECO:0000305|PubMed:16604269"
FT                   /id="PRO_0000234822"
SQ   SEQUENCE   68 AA;  7196 MW;  7741FE20D5FCAC13 CRC64;
     MRCVPVFIIL LLLASPAAPK SLETRIQNDL IRAGLTDADL KTEKGFLSGL LNVAGSVCCK
     VDTSCCSN