ID   CT52_CONLT              Reviewed;          68 AA.
AC   Q1A3Q9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Conotoxin Lt5.2 {ECO:0000303|PubMed:16908117};
DE   AltName: Full=Lt5b {ECO:0000312|EMBL:ABC70191.1};
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA   Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA   Dong M., Chen S., Xu A.;
RT   "Diversity and evolution of conotoxins based on gene expression profiling
RT   of Conus litteratus.";
RL   Genomics 88:809-819(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:16908117}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:16908117}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; DQ345355; ABC70191.1; -; mRNA.
DR   AlphaFoldDB; Q1A3Q9; -.
DR   ConoServer; 1142; Lt5b precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..54
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000315425"
FT   PEPTIDE         55..68
FT                   /note="Conotoxin Lt5.2"
FT                   /id="PRO_0000315426"
SQ   SEQUENCE   68 AA;  7167 MW;  62B40D06000F9F33 CRC64;
     MLCLPVFIIL LLLASPAAPK SLETRIQNDL IRAGLTDADL KTEKGFLSGL LNVAGSVCCK
     VDTSCCSN