ID   CT52_CONPL              Reviewed;          64 AA.
AC   P0C637; A8RCQ6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Conotoxin Pu5.2 {ECO:0000303|PubMed:17933431};
DE   Flags: Precursor;
OS   Conus pulicarius (Flea-bitten cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=93154;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17933431; DOI=10.1016/j.peptides.2007.08.026;
RA   Peng C., Wu X., Han Y., Yuan D., Chi C., Wang C.;
RT   "Identification of six novel T-1 conotoxins from Conus pulicarius by
RT   molecular cloning.";
RL   Peptides 28:2116-2124(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC).
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; EF488464; ABS01336.1; -; mRNA.
DR   AlphaFoldDB; P0C637; -.
DR   ConoServer; 2791; Pu5.2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..52
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000315445"
FT   PEPTIDE         53..63
FT                   /note="Conotoxin Pu5.2"
FT                   /id="PRO_0000315446"
FT   MOD_RES         63
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   64 AA;  7058 MW;  2F704720F005F3BA CRC64;
     MRCVPVFVIL LLLIASTPSV DARPNPKDDV PLASFHGADN ANRILRTLWN LRGCCEDKTC
     CFIG