ID   CT52_CONQU              Reviewed;          62 AA.
AC   P0DJC5;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Conotoxin Qc5.2 {ECO:0000305};
DE   Flags: Precursor;
OS   Conus quercinus (Oak cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=101313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Walker C., Shetty R., Olivera B.M., Hooper D., Jacobsen R., Steele D.,
RA   Jones R.M.;
RT   "Tau-conotoxin peptides.";
RL   Patent number JP2002536970, 05-NOV-2002.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC).
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; BD270193; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   AlphaFoldDB; P0DJC5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..48
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000415311"
FT   PEPTIDE         51..60
FT                   /note="Conotoxin Qc5.2"
FT                   /id="PRO_0000415312"
FT   MOD_RES         60
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   62 AA;  6824 MW;  5D4EDC58F32635F9 CRC64;
     MRCVPVFIIL LLLSPSAPSV DAHPMTKDDV PQASLHDDAK RTLQVPWMKR GCCAMLTCCV
     GR