ID   CT53_CONLT              Reviewed;          62 AA.
AC   Q3YEH3; Q1A3R2;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Conotoxin Lt5.3 {ECO:0000303|PubMed:16908117};
DE   AltName: Full=LeD33 {ECO:0000303|PubMed:16999774};
DE   AltName: Full=Lt5c {ECO:0000312|EMBL:ABC70188.1};
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16999774; DOI=10.1111/j.1747-0285.2006.00422.x;
RA   Luo S., Zhangsun D., Wu Y., Zhu X., Xie L., Hu Y., Zhang J., Zhao X.;
RT   "Identification and molecular diversity of T-superfamily conotoxins from
RT   Conus lividus and Conus litteratus.";
RL   Chem. Biol. Drug Des. 68:97-106(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA   Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA   Dong M., Chen S., Xu A.;
RT   "Diversity and evolution of conotoxins based on gene expression profiling
RT   of Conus litteratus.";
RL   Genomics 88:809-819(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:16999774}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:16999774}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; DQ141140; AAZ85405.1; -; mRNA.
DR   EMBL; DQ345352; ABC70188.1; -; mRNA.
DR   AlphaFoldDB; Q3YEH3; -.
DR   ConoServer; 1677; Lt5c precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..48
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000274064"
FT   PEPTIDE         51..62
FT                   /note="Conotoxin Lt5.3"
FT                   /id="PRO_0000274065"
FT   CONFLICT        3..5
FT                   /note="FLP -> CLL (in Ref. 2; ABC70188)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   62 AA;  7153 MW;  F0F2C758454990DD CRC64;
     MRFLPVFIIL LLLIPSAPSV DAQPMTKDDV PLSSLHDNAK RALQMFWNKR DCCPAKMFCC
     QW