ID   CT54B_CONMR             Reviewed;          54 AA.
AC   Q68IP5;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Conotoxin mr5.4b {ECO:0000303|PubMed:15733570};
DE   Flags: Precursor; Fragment;
OS   Conus marmoreus (Marble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=42752;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=15733570; DOI=10.1016/j.toxicon.2004.12.008;
RA   Han Y.-H., Wang Q., Jiang H., Miao X.-W., Chen J.-S., Chi C.-W.;
RT   "Sequence diversity of T-superfamily conotoxins from Conus marmoreus.";
RL   Toxicon 45:481-487(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC).
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY687346; AAT97072.1; -; mRNA.
DR   AlphaFoldDB; Q68IP5; -.
DR   SMR; Q68IP5; -.
DR   ConoServer; 877; Mr5.4b precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Gamma-carboxyglutamic acid; Secreted; Signal; Toxin.
FT   SIGNAL          <1..14
FT                   /evidence="ECO:0000255"
FT   PROPEP          15..40
FT                   /id="PRO_0000035039"
FT   PEPTIDE         43..54
FT                   /note="Conotoxin mr5.4b"
FT                   /id="PRO_0000035040"
FT   MOD_RES         52
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   54 AA;  6048 MW;  A48F1BEB3097878C CRC64;
     ILLLLIASAP SVDAQLKTKD DVPLASFHAN VKRTLQKLLN KRCCQIVPQC CEWN