ID   CT54_CONAE              Reviewed;          58 AA.
AC   Q9BP47;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Conotoxin Ar5.4 {ECO:0000305};
DE   AltName: Full=Conotoxin ArMLCL-D02173 {ECO:0000312|EMBL:AAG60531.1};
DE   Flags: Precursor; Fragment;
OS   Conus arenatus (Sand-dusted cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:11158371}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:11158371}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000305}.
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DR   EMBL; AF215115; AAG60531.1; -; mRNA.
DR   AlphaFoldDB; Q9BP47; -.
DR   SMR; Q9BP47; -.
DR   ConoServer; 1557; Ar5.4 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   PROPEP          <1..20
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000404956"
FT   PEPTIDE         21..58
FT                   /note="Conotoxin Ar5.4"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000404957"
FT   NON_TER         1
SQ   SEQUENCE   58 AA;  6273 MW;  B21E8E04B1BC36CA CRC64;
     RIQSDLIRAA LEDADMKNEK NILSSIMGSL GTIGNVVGNV CCSITKSCCA SWLFPRLE