ID   CT54_CONIM              Reviewed;          58 AA.
AC   H8Y1U0;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Conotoxin Im5.4 {ECO:0000312|EMBL:ADZ74140.1};
DE   AltName: Full=Conopeptide im023 {ECO:0000303|PubMed:30893765, ECO:0000312|EMBL:AME17681.1};
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=22781954; DOI=10.1016/j.toxicon.2012.06.011;
RA   Liu Z., Li H., Liu N., Wu C., Jiang J., Yue J., Jing Y., Dai Q.;
RT   "Diversity and evolution of conotoxins in Conus virgo, Conus eburneus,
RT   Conus imperialis and Conus marmoreus from the South China Sea.";
RL   Toxicon 60:982-989(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30893765; DOI=10.3390/md17030177;
RA   Jin A.H., Dutertre S., Dutt M., Lavergne V., Jones A., Lewis R.J.,
RA   Alewood P.F.;
RT   "Transcriptomic-proteomic correlation in the predation-evoked venom of the
RT   cone snail, Conus imperialis.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30893765}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30893765}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin T superfamily. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JF322911; ADZ74140.1; -; mRNA.
DR   EMBL; KT377417; AME17681.1; -; mRNA.
DR   AlphaFoldDB; H8Y1U0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..28
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000450995"
FT   PEPTIDE         29..58
FT                   /note="Conotoxin Im5.4"
FT                   /id="PRO_5007666723"
SQ   SEQUENCE   58 AA;  5886 MW;  39E81715BA6565E7 CRC64;
     MRCLPVVVFL LLLLSAAAAP GVGSKTERLP GLTSSGDSDE SLPFLNTICC WSGACCGG